Marginal dietary copper restriction induces cardiomyopathy in rats

Yan Li, Lipeng Wang, Dale A. Schuschke, Zhanxiang Zhou, Jack T. Saari, Yujian Kang

Research output: Contribution to journalArticle

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Abstract

Prior studies have provided evidence of marginal dietary copper restriction in humans. The present study was undertaken to examine in a rat model the effect of a long-term marginal dietary Cu deficiency on the heart. Male adult Sprague-Dawley rats were fed AIN-76 diet containing 6.0 (control), 3.0, or 1.5 mg Cu/kg starting at 11 wk of age. Groups of rats were killed at 6, 9, 12, 15, or 18 mo after initiation of feeding, and the same experiment was repeated once. The only systemic change induced by marginal dietary Cu restriction (P < 0.05) was depression of organ Cu concentrations in rats fed 1.5 mg Cu/kg diet. Cardiac pathological manifestations in rats fed lower Cu diets were evidenced by histopathological, ultrastructural, and functional alterations. Myocyte hypertrophy and excessive collagen deposition in the heart occurred in rats fed 1.5 mg Cu/kg diet. Ultrastructural changes, including increased number and volume of mitochondria along with disruption of cristae structure, diastolic and systolic dysfunction, and electrocardiograph alterations, occurred in rats fed 1.5 or 3.0 mg Cu/kg diet. These results demonstrate that, in the absence of most indications of systemic Cu deficiency, heart morphology and function are sensitive to marginal Cu deficiency.

Original languageEnglish (US)
Pages (from-to)2130-2136
Number of pages7
JournalJournal of Nutrition
Volume135
Issue number9
StatePublished - Sep 1 2005

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Cardiomyopathies
Copper
Diet
Mitochondrial Size
Muscle Cells
Hypertrophy
Sprague Dawley Rats
Electrocardiography
Collagen

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Li, Y., Wang, L., Schuschke, D. A., Zhou, Z., Saari, J. T., & Kang, Y. (2005). Marginal dietary copper restriction induces cardiomyopathy in rats. Journal of Nutrition, 135(9), 2130-2136.

Marginal dietary copper restriction induces cardiomyopathy in rats. / Li, Yan; Wang, Lipeng; Schuschke, Dale A.; Zhou, Zhanxiang; Saari, Jack T.; Kang, Yujian.

In: Journal of Nutrition, Vol. 135, No. 9, 01.09.2005, p. 2130-2136.

Research output: Contribution to journalArticle

Li, Y, Wang, L, Schuschke, DA, Zhou, Z, Saari, JT & Kang, Y 2005, 'Marginal dietary copper restriction induces cardiomyopathy in rats', Journal of Nutrition, vol. 135, no. 9, pp. 2130-2136.
Li Y, Wang L, Schuschke DA, Zhou Z, Saari JT, Kang Y. Marginal dietary copper restriction induces cardiomyopathy in rats. Journal of Nutrition. 2005 Sep 1;135(9):2130-2136.
Li, Yan ; Wang, Lipeng ; Schuschke, Dale A. ; Zhou, Zhanxiang ; Saari, Jack T. ; Kang, Yujian. / Marginal dietary copper restriction induces cardiomyopathy in rats. In: Journal of Nutrition. 2005 ; Vol. 135, No. 9. pp. 2130-2136.
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