Marine microalgae bioengineered Schizochytrium sp. meal hydrolysates inhibits acute inflammation

Xiaoli Wang, Heng Wang, Joseph Pierre, Sheng Wang, Huifang Huang, Jun Zhang, Shuangzhen Liang, Qingzhu Zeng, Chenqing Zhang, Meijuan Huang, Chengxu Ruan, Juan Lin, Hao Li

Research output: Contribution to journalArticle

Abstract

Bioengineered marine microalgae Schizochytrium sp. is currently used to produce docosahexaenoic acid (DHA). However, following DHA extraction, the remaining protein-rich materials are not well utilized. In this study, we report that marine microalgae bioengineered Schizochytrium sp. hydrolysate (MESH), which exhibits a unique peptide profile as identified by Ultra Performance Liquid Chromatography coupled with Q-TOF mass spectrometry(UPLC/Q-TOF-MS), ameliorated bowel inflammation in mice. In a mouse model of experimentalcolitis induced by dextran sulfate sodium, compared with the control mice, the mice treated with MESH were highly resistant to colitis, as demonstrated by marked reductions in body weight loss, clinical colitis scores, colonic histological damage, and colonic inflammation. Mechanistically, MESH attenuated the induction of pro-inflammatory cytokines and increased the induction of anti-inflammatory cytokines. MESH also promoted the proliferation of colonic crypt stem cells and progenitor cells required for crypt repair. Collectively, these results reveal a previously unrecognized role of MESH as a potential anti-inflammatory treatment for colitis.

Original languageEnglish (US)
Article number9848
JournalScientific reports
Volume8
Issue number1
DOIs
StatePublished - Dec 1 2018

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Microalgae
Meals
Colitis
Inflammation
Docosahexaenoic Acids
Anti-Inflammatory Agents
Stem Cells
Cytokines
Dextran Sulfate
Liquid Chromatography
Weight Loss
Mass Spectrometry
Body Weight
Peptides
Proteins

All Science Journal Classification (ASJC) codes

  • General

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Marine microalgae bioengineered Schizochytrium sp. meal hydrolysates inhibits acute inflammation. / Wang, Xiaoli; Wang, Heng; Pierre, Joseph; Wang, Sheng; Huang, Huifang; Zhang, Jun; Liang, Shuangzhen; Zeng, Qingzhu; Zhang, Chenqing; Huang, Meijuan; Ruan, Chengxu; Lin, Juan; Li, Hao.

In: Scientific reports, Vol. 8, No. 1, 9848, 01.12.2018.

Research output: Contribution to journalArticle

Wang, X, Wang, H, Pierre, J, Wang, S, Huang, H, Zhang, J, Liang, S, Zeng, Q, Zhang, C, Huang, M, Ruan, C, Lin, J & Li, H 2018, 'Marine microalgae bioengineered Schizochytrium sp. meal hydrolysates inhibits acute inflammation', Scientific reports, vol. 8, no. 1, 9848. https://doi.org/10.1038/s41598-018-28064-y
Wang, Xiaoli ; Wang, Heng ; Pierre, Joseph ; Wang, Sheng ; Huang, Huifang ; Zhang, Jun ; Liang, Shuangzhen ; Zeng, Qingzhu ; Zhang, Chenqing ; Huang, Meijuan ; Ruan, Chengxu ; Lin, Juan ; Li, Hao. / Marine microalgae bioengineered Schizochytrium sp. meal hydrolysates inhibits acute inflammation. In: Scientific reports. 2018 ; Vol. 8, No. 1.
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