Matrix metalloproteinas-9 functional promoter polymorphism 1562C>T increased risk of early-onset coronary artery disease

Massoud Saedi, Asad Vaisi-Raygani, Shahnaz Khaghani, Ahmad Shariftabrizi, M. Rezaie, Parvin Pasalar, Zohreh Rahimi, Tayebeh Pourmotabbed

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Abstract

The Matrix metalloproteinas-9 functional promoter polymorphism 1562C>T may be considered an important genetic determinant of early-onset coronary artery disease (ECAD). In this study, association between MMP-9 1562C>T allele with plasma MMP-9 activity, homocysteine and lipid-lipoproteins level and ECAD in Iranian subjects was investigated. This case-control study consisted of 53 ECAD patients (age < 55 years) and unrelated late-onsets CAD (age > 70 years) who angiographically had at least 50% stenosis. MMP-9 1562C>T polymorphism was detected by PCRRFLP, plasma MMP-9 activity, serum lipid and homocysteine levels were determined by gelatin gel zymography, enzyme assay and by HPLC, respectively. The presence of MMP-9 1562C>T allele was found to be associated with ECAD (OR = 3.2, P = 0.001). The ECAD patients with MMP-9 1562C>T allele had higher MMP-9 activity (P = 0.001), LDL-C (P = 0.045), TC (P = 0.02) and homocysteine (P = 0.01) levels than the LCAD subjects. MMP-9 1562C>T allele is a risk factor for ECAD. The carriers of this allele have high levels of MMP-9 activity, LDL-C, TC and homocysteine (P = 0.01), thus, are more likely to develop myocardial infarction and CAD at young age (less than 55 years).

Original languageEnglish (US)
Pages (from-to)555-562
Number of pages8
JournalMolecular Biology Reports
Volume39
Issue number1
DOIs
StatePublished - Jan 1 2012

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Matrix Metalloproteinases
Coronary Artery Disease
Homocysteine
Alleles
Lipids
Enzyme Assays
Gelatin
Lipoproteins
Case-Control Studies
Pathologic Constriction
Gels
Myocardial Infarction
High Pressure Liquid Chromatography
Serum

All Science Journal Classification (ASJC) codes

  • Genetics
  • Molecular Biology

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Matrix metalloproteinas-9 functional promoter polymorphism 1562C>T increased risk of early-onset coronary artery disease. / Saedi, Massoud; Vaisi-Raygani, Asad; Khaghani, Shahnaz; Shariftabrizi, Ahmad; Rezaie, M.; Pasalar, Parvin; Rahimi, Zohreh; Pourmotabbed, Tayebeh.

In: Molecular Biology Reports, Vol. 39, No. 1, 01.01.2012, p. 555-562.

Research output: Contribution to journalArticle

Saedi, Massoud ; Vaisi-Raygani, Asad ; Khaghani, Shahnaz ; Shariftabrizi, Ahmad ; Rezaie, M. ; Pasalar, Parvin ; Rahimi, Zohreh ; Pourmotabbed, Tayebeh. / Matrix metalloproteinas-9 functional promoter polymorphism 1562C>T increased risk of early-onset coronary artery disease. In: Molecular Biology Reports. 2012 ; Vol. 39, No. 1. pp. 555-562.
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