Matrix outdoors

Unfurled and furled

Research output: Contribution to journalArticle

Abstract

Sclerotic and contracted heart valve leaflets are like furled sails of Winter. They have been actively, albeit slowly, converted from unfurled sails of Summer by a population of a-smooth muscle actincontainmg, type I and III collagen-producing myofibroblasts. Signals regulating myofibroblast collagen turnover and contraction merit investigation. Valves are neither inert nor passive tissue. Let's dare to shed the conventional in search of a fuller understanding of the pathogenesis of valvular sclerosis and contraction. In so doing, we may find insights seminal to the prevention and perhaps even the regression of valvular disease in all parts of the world.

Original languageEnglish (US)
Pages (from-to)369-372
Number of pages4
JournalHerz Kreislauf
Volume30
Issue number11
StatePublished - Dec 1 1998

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Myofibroblasts
Collagen Type III
Heart Valves
Sclerosis
Collagen Type I
Smooth Muscle
Collagen
Population

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Matrix outdoors : Unfurled and furled. / Weber, Karl.

In: Herz Kreislauf, Vol. 30, No. 11, 01.12.1998, p. 369-372.

Research output: Contribution to journalArticle

Weber, K 1998, 'Matrix outdoors: Unfurled and furled', Herz Kreislauf, vol. 30, no. 11, pp. 369-372.
Weber, Karl. / Matrix outdoors : Unfurled and furled. In: Herz Kreislauf. 1998 ; Vol. 30, No. 11. pp. 369-372.
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