MDMA (ecstasy) effects in pubescent rats

Males are more sensitive than females

Julie Koenig, Christine Lazarus, Hélène Jeltsch, Sami Ben Hamida, Céline Riegert, Christian Kelche, Byron Jones, Jean Christophe Cassel

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

In Experiment 1, we assessed the effects of 3,4- methylenedioxymethamphetamine (MDMA) on locomotor activity in pubescent male and female Long-Evans rats. Thirty-nine day old rats were injected ip with 10 mg/kg of MDMA (ambient temperature 25°C) three times at 2 h intervals. Initially, females showed greater locomotor activation by the drug than males, however after the second injection, males showed greater hyperlocomotion. After the third injection, 3 of 10 females and all of the males died. In the surviving females, we observed serotonin depletion in cortex and hippocampus, but catecholaminergic markers were unaltered. In Experiment 2, male and female rats were repeatedly injected with saline or 2, 5 or 10 mg/kg MDMA and body temperature was measured (ambient temperature 21.5°C). After the third injection of 10 mg/kg MDMA, the MDMA-induced hyperthermia was greater in males than in females (about + 0.8°C); at the lower dose, no difference was observed. Probably because of the lower ambient temperature, only 1 female and 2 males succumbed to the MDMA treatment, and MDMA induced less serotonin depletion than in the first experiment, with no difference between females and males. Thus, pubescent males appear to be more sensitive than females to locomotor and hyperpyretic effects of MDMA. This sex-dependent effect, which is at variance with previously reported dimorphisms in psychostimulant effects, is discussed in terms of possible differences in dopamine D1 and D 2 receptors at pubescence, or other factors related to drug metabolism.

Original languageEnglish (US)
Pages (from-to)635-644
Number of pages10
JournalPharmacology Biochemistry and Behavior
Volume81
Issue number3
DOIs
StatePublished - Jul 1 2005
Externally publishedYes

Fingerprint

N-Methyl-3,4-methylenedioxyamphetamine
Rats
Serotonin
Injections
Temperature
Experiments
Long Evans Rats
Induced Hyperthermia
Metabolism
Pharmaceutical Preparations
Locomotion
Body Temperature
Dopamine
Chemical activation
Hippocampus

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

Cite this

Koenig, J., Lazarus, C., Jeltsch, H., Hamida, S. B., Riegert, C., Kelche, C., ... Cassel, J. C. (2005). MDMA (ecstasy) effects in pubescent rats: Males are more sensitive than females. Pharmacology Biochemistry and Behavior, 81(3), 635-644. https://doi.org/10.1016/j.pbb.2005.04.014

MDMA (ecstasy) effects in pubescent rats : Males are more sensitive than females. / Koenig, Julie; Lazarus, Christine; Jeltsch, Hélène; Hamida, Sami Ben; Riegert, Céline; Kelche, Christian; Jones, Byron; Cassel, Jean Christophe.

In: Pharmacology Biochemistry and Behavior, Vol. 81, No. 3, 01.07.2005, p. 635-644.

Research output: Contribution to journalArticle

Koenig, J, Lazarus, C, Jeltsch, H, Hamida, SB, Riegert, C, Kelche, C, Jones, B & Cassel, JC 2005, 'MDMA (ecstasy) effects in pubescent rats: Males are more sensitive than females', Pharmacology Biochemistry and Behavior, vol. 81, no. 3, pp. 635-644. https://doi.org/10.1016/j.pbb.2005.04.014
Koenig, Julie ; Lazarus, Christine ; Jeltsch, Hélène ; Hamida, Sami Ben ; Riegert, Céline ; Kelche, Christian ; Jones, Byron ; Cassel, Jean Christophe. / MDMA (ecstasy) effects in pubescent rats : Males are more sensitive than females. In: Pharmacology Biochemistry and Behavior. 2005 ; Vol. 81, No. 3. pp. 635-644.
@article{0523d7ecd865433ea504faa8b48ae740,
title = "MDMA (ecstasy) effects in pubescent rats: Males are more sensitive than females",
abstract = "In Experiment 1, we assessed the effects of 3,4- methylenedioxymethamphetamine (MDMA) on locomotor activity in pubescent male and female Long-Evans rats. Thirty-nine day old rats were injected ip with 10 mg/kg of MDMA (ambient temperature 25°C) three times at 2 h intervals. Initially, females showed greater locomotor activation by the drug than males, however after the second injection, males showed greater hyperlocomotion. After the third injection, 3 of 10 females and all of the males died. In the surviving females, we observed serotonin depletion in cortex and hippocampus, but catecholaminergic markers were unaltered. In Experiment 2, male and female rats were repeatedly injected with saline or 2, 5 or 10 mg/kg MDMA and body temperature was measured (ambient temperature 21.5°C). After the third injection of 10 mg/kg MDMA, the MDMA-induced hyperthermia was greater in males than in females (about + 0.8°C); at the lower dose, no difference was observed. Probably because of the lower ambient temperature, only 1 female and 2 males succumbed to the MDMA treatment, and MDMA induced less serotonin depletion than in the first experiment, with no difference between females and males. Thus, pubescent males appear to be more sensitive than females to locomotor and hyperpyretic effects of MDMA. This sex-dependent effect, which is at variance with previously reported dimorphisms in psychostimulant effects, is discussed in terms of possible differences in dopamine D1 and D 2 receptors at pubescence, or other factors related to drug metabolism.",
author = "Julie Koenig and Christine Lazarus and H{\'e}l{\`e}ne Jeltsch and Hamida, {Sami Ben} and C{\'e}line Riegert and Christian Kelche and Byron Jones and Cassel, {Jean Christophe}",
year = "2005",
month = "7",
day = "1",
doi = "10.1016/j.pbb.2005.04.014",
language = "English (US)",
volume = "81",
pages = "635--644",
journal = "Pharmacology Biochemistry and Behavior",
issn = "0091-3057",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - MDMA (ecstasy) effects in pubescent rats

T2 - Males are more sensitive than females

AU - Koenig, Julie

AU - Lazarus, Christine

AU - Jeltsch, Hélène

AU - Hamida, Sami Ben

AU - Riegert, Céline

AU - Kelche, Christian

AU - Jones, Byron

AU - Cassel, Jean Christophe

PY - 2005/7/1

Y1 - 2005/7/1

N2 - In Experiment 1, we assessed the effects of 3,4- methylenedioxymethamphetamine (MDMA) on locomotor activity in pubescent male and female Long-Evans rats. Thirty-nine day old rats were injected ip with 10 mg/kg of MDMA (ambient temperature 25°C) three times at 2 h intervals. Initially, females showed greater locomotor activation by the drug than males, however after the second injection, males showed greater hyperlocomotion. After the third injection, 3 of 10 females and all of the males died. In the surviving females, we observed serotonin depletion in cortex and hippocampus, but catecholaminergic markers were unaltered. In Experiment 2, male and female rats were repeatedly injected with saline or 2, 5 or 10 mg/kg MDMA and body temperature was measured (ambient temperature 21.5°C). After the third injection of 10 mg/kg MDMA, the MDMA-induced hyperthermia was greater in males than in females (about + 0.8°C); at the lower dose, no difference was observed. Probably because of the lower ambient temperature, only 1 female and 2 males succumbed to the MDMA treatment, and MDMA induced less serotonin depletion than in the first experiment, with no difference between females and males. Thus, pubescent males appear to be more sensitive than females to locomotor and hyperpyretic effects of MDMA. This sex-dependent effect, which is at variance with previously reported dimorphisms in psychostimulant effects, is discussed in terms of possible differences in dopamine D1 and D 2 receptors at pubescence, or other factors related to drug metabolism.

AB - In Experiment 1, we assessed the effects of 3,4- methylenedioxymethamphetamine (MDMA) on locomotor activity in pubescent male and female Long-Evans rats. Thirty-nine day old rats were injected ip with 10 mg/kg of MDMA (ambient temperature 25°C) three times at 2 h intervals. Initially, females showed greater locomotor activation by the drug than males, however after the second injection, males showed greater hyperlocomotion. After the third injection, 3 of 10 females and all of the males died. In the surviving females, we observed serotonin depletion in cortex and hippocampus, but catecholaminergic markers were unaltered. In Experiment 2, male and female rats were repeatedly injected with saline or 2, 5 or 10 mg/kg MDMA and body temperature was measured (ambient temperature 21.5°C). After the third injection of 10 mg/kg MDMA, the MDMA-induced hyperthermia was greater in males than in females (about + 0.8°C); at the lower dose, no difference was observed. Probably because of the lower ambient temperature, only 1 female and 2 males succumbed to the MDMA treatment, and MDMA induced less serotonin depletion than in the first experiment, with no difference between females and males. Thus, pubescent males appear to be more sensitive than females to locomotor and hyperpyretic effects of MDMA. This sex-dependent effect, which is at variance with previously reported dimorphisms in psychostimulant effects, is discussed in terms of possible differences in dopamine D1 and D 2 receptors at pubescence, or other factors related to drug metabolism.

UR - http://www.scopus.com/inward/record.url?scp=22044431879&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=22044431879&partnerID=8YFLogxK

U2 - 10.1016/j.pbb.2005.04.014

DO - 10.1016/j.pbb.2005.04.014

M3 - Article

VL - 81

SP - 635

EP - 644

JO - Pharmacology Biochemistry and Behavior

JF - Pharmacology Biochemistry and Behavior

SN - 0091-3057

IS - 3

ER -