MDMA: Interactions with other psychoactive drugs

Wael M.Y. Mohamed, Sami Ben Hamida, Jean Christophe Cassel, Anne Pereira De Vasconcelos, Byron Jones

Research output: Contribution to journalReview article

40 Citations (Scopus)

Abstract

3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) is one of the most widely abused illegal drugs. Some users self-report euphoria and an increased perception and feeling of closeness to others. When taken in warm environments, MDMA users may develop acute complications with potential fatal consequences. In rodents, MDMA increases locomotor activity and, depending on ambient temperature, may produce a dose-dependent, potentially lethal hyperthermia. Like most other recreational drugs, MDMA is frequently taken in combination with other substances including tobacco, EtOH, marijuana, amphetamines, cocaine and, caffeine. Although polydrug use is very common, the understanding of the effects of this multiple substance use, as well as the analysis of consequences of different drug-drug associations, received rather little attention. The purpose of this review is to summarize our current knowledge about the changes on MDMA-related behavior, pharmacology, and neurotoxicity associated with co-consumption of other drugs of abuse and psychoactive agents.

Original languageEnglish (US)
Pages (from-to)759-774
Number of pages16
JournalPharmacology Biochemistry and Behavior
Volume99
Issue number4
DOIs
StatePublished - Oct 1 2011
Externally publishedYes

Fingerprint

N-Methyl-3,4-methylenedioxyamphetamine
Psychotropic Drugs
Street Drugs
Pharmaceutical Preparations
Amphetamines
Tobacco
Cannabis
Locomotion
Caffeine
Cocaine
Self Report
Rodentia
Emotions
Fever
Pharmacology
Temperature

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

Cite this

Mohamed, W. M. Y., Hamida, S. B., Cassel, J. C., De Vasconcelos, A. P., & Jones, B. (2011). MDMA: Interactions with other psychoactive drugs. Pharmacology Biochemistry and Behavior, 99(4), 759-774. https://doi.org/10.1016/j.pbb.2011.06.032

MDMA : Interactions with other psychoactive drugs. / Mohamed, Wael M.Y.; Hamida, Sami Ben; Cassel, Jean Christophe; De Vasconcelos, Anne Pereira; Jones, Byron.

In: Pharmacology Biochemistry and Behavior, Vol. 99, No. 4, 01.10.2011, p. 759-774.

Research output: Contribution to journalReview article

Mohamed, WMY, Hamida, SB, Cassel, JC, De Vasconcelos, AP & Jones, B 2011, 'MDMA: Interactions with other psychoactive drugs', Pharmacology Biochemistry and Behavior, vol. 99, no. 4, pp. 759-774. https://doi.org/10.1016/j.pbb.2011.06.032
Mohamed, Wael M.Y. ; Hamida, Sami Ben ; Cassel, Jean Christophe ; De Vasconcelos, Anne Pereira ; Jones, Byron. / MDMA : Interactions with other psychoactive drugs. In: Pharmacology Biochemistry and Behavior. 2011 ; Vol. 99, No. 4. pp. 759-774.
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