Mean platelet volume and mortality risk in a national incident hemodialysis cohort

Steven Kim, Miklos Z. Molnar, Gregg C. Fonarow, Elani Streja, Jiaxi Wang, Daniel L. Gillen, Rajnish Mehrotra, Steven M. Brunelli, Csaba Kovesdy, Kamyar Kalantar-Zadeh, Connie M. Rhee

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Abstract

Background Higher mean platelet volume (MPV) is an indicator of larger, reactive platelets, and has been associated with a higher risk of thrombosis and cardiovascular events in the general population. Hemodialysis patients have a higher risk for cardiovascular death and predisposition to platelet dysfunction (thrombosis and bleeding diathesis), but the relationship between MPV and mortality in this population is unknown. Methods Among a 5-year cohort (1/2007–12/2011) of 149,118 incident hemodialysis patients from a large national dialysis organization, we examined the association between MPV and all-cause mortality. In primary analyses, we granularly analyzed MPV across five categories: 7.2–7.5, > 7.5–9.5, > 9.5–11.5, > 11.5–13.5, and > 13.5–15.0 fL. In secondary analyses, we examined MPV categorized as low, normal, and high based on thresholds in the general population: 7.2–7.5, > 7.5–11.5, and > 11.5 fL, respectively. Associations between baseline and time-dependent MPV with mortality were estimated using traditional and time-dependent Cox models in order to determine long-term and short-term exposure—mortality associations, respectively, using three adjustment levels: unadjusted, case-mix, and case-mix + laboratory models. Results In primary analyses, higher baseline and time-dependent MPV levels were associated with incrementally higher death risk in case-mix + laboratory analyses (reference: > 9.5–11.5 fL). In secondary analyses, high baseline and time-dependent MPV levels were associated with higher mortality, whereas low MPV was associated with lower death risk across all multivariable models (reference: normal MPV). Conclusions Hemodialysis patients with higher MPV have heightened mortality risk. Further studies are needed to determine the pathophysiologic basis for the higher risk, and if modification of MPV ameliorates mortality in this population.

Original languageEnglish (US)
Pages (from-to)862-870
Number of pages9
JournalInternational Journal of Cardiology
Volume220
DOIs
StatePublished - Oct 1 2016

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Mean Platelet Volume
Renal Dialysis
Mortality
Diagnosis-Related Groups
Population
Thrombosis
Blood Platelets
Disease Susceptibility
Proportional Hazards Models
Dialysis

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Kim, S., Molnar, M. Z., Fonarow, G. C., Streja, E., Wang, J., Gillen, D. L., ... Rhee, C. M. (2016). Mean platelet volume and mortality risk in a national incident hemodialysis cohort. International Journal of Cardiology, 220, 862-870. https://doi.org/10.1016/j.ijcard.2016.06.074

Mean platelet volume and mortality risk in a national incident hemodialysis cohort. / Kim, Steven; Molnar, Miklos Z.; Fonarow, Gregg C.; Streja, Elani; Wang, Jiaxi; Gillen, Daniel L.; Mehrotra, Rajnish; Brunelli, Steven M.; Kovesdy, Csaba; Kalantar-Zadeh, Kamyar; Rhee, Connie M.

In: International Journal of Cardiology, Vol. 220, 01.10.2016, p. 862-870.

Research output: Contribution to journalArticle

Kim, S, Molnar, MZ, Fonarow, GC, Streja, E, Wang, J, Gillen, DL, Mehrotra, R, Brunelli, SM, Kovesdy, C, Kalantar-Zadeh, K & Rhee, CM 2016, 'Mean platelet volume and mortality risk in a national incident hemodialysis cohort', International Journal of Cardiology, vol. 220, pp. 862-870. https://doi.org/10.1016/j.ijcard.2016.06.074
Kim, Steven ; Molnar, Miklos Z. ; Fonarow, Gregg C. ; Streja, Elani ; Wang, Jiaxi ; Gillen, Daniel L. ; Mehrotra, Rajnish ; Brunelli, Steven M. ; Kovesdy, Csaba ; Kalantar-Zadeh, Kamyar ; Rhee, Connie M. / Mean platelet volume and mortality risk in a national incident hemodialysis cohort. In: International Journal of Cardiology. 2016 ; Vol. 220. pp. 862-870.
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abstract = "Background Higher mean platelet volume (MPV) is an indicator of larger, reactive platelets, and has been associated with a higher risk of thrombosis and cardiovascular events in the general population. Hemodialysis patients have a higher risk for cardiovascular death and predisposition to platelet dysfunction (thrombosis and bleeding diathesis), but the relationship between MPV and mortality in this population is unknown. Methods Among a 5-year cohort (1/2007–12/2011) of 149,118 incident hemodialysis patients from a large national dialysis organization, we examined the association between MPV and all-cause mortality. In primary analyses, we granularly analyzed MPV across five categories: 7.2–7.5, > 7.5–9.5, > 9.5–11.5, > 11.5–13.5, and > 13.5–15.0 fL. In secondary analyses, we examined MPV categorized as low, normal, and high based on thresholds in the general population: 7.2–7.5, > 7.5–11.5, and > 11.5 fL, respectively. Associations between baseline and time-dependent MPV with mortality were estimated using traditional and time-dependent Cox models in order to determine long-term and short-term exposure—mortality associations, respectively, using three adjustment levels: unadjusted, case-mix, and case-mix + laboratory models. Results In primary analyses, higher baseline and time-dependent MPV levels were associated with incrementally higher death risk in case-mix + laboratory analyses (reference: > 9.5–11.5 fL). In secondary analyses, high baseline and time-dependent MPV levels were associated with higher mortality, whereas low MPV was associated with lower death risk across all multivariable models (reference: normal MPV). Conclusions Hemodialysis patients with higher MPV have heightened mortality risk. Further studies are needed to determine the pathophysiologic basis for the higher risk, and if modification of MPV ameliorates mortality in this population.",
author = "Steven Kim and Molnar, {Miklos Z.} and Fonarow, {Gregg C.} and Elani Streja and Jiaxi Wang and Gillen, {Daniel L.} and Rajnish Mehrotra and Brunelli, {Steven M.} and Csaba Kovesdy and Kamyar Kalantar-Zadeh and Rhee, {Connie M.}",
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AU - Kim, Steven

AU - Molnar, Miklos Z.

AU - Fonarow, Gregg C.

AU - Streja, Elani

AU - Wang, Jiaxi

AU - Gillen, Daniel L.

AU - Mehrotra, Rajnish

AU - Brunelli, Steven M.

AU - Kovesdy, Csaba

AU - Kalantar-Zadeh, Kamyar

AU - Rhee, Connie M.

PY - 2016/10/1

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N2 - Background Higher mean platelet volume (MPV) is an indicator of larger, reactive platelets, and has been associated with a higher risk of thrombosis and cardiovascular events in the general population. Hemodialysis patients have a higher risk for cardiovascular death and predisposition to platelet dysfunction (thrombosis and bleeding diathesis), but the relationship between MPV and mortality in this population is unknown. Methods Among a 5-year cohort (1/2007–12/2011) of 149,118 incident hemodialysis patients from a large national dialysis organization, we examined the association between MPV and all-cause mortality. In primary analyses, we granularly analyzed MPV across five categories: 7.2–7.5, > 7.5–9.5, > 9.5–11.5, > 11.5–13.5, and > 13.5–15.0 fL. In secondary analyses, we examined MPV categorized as low, normal, and high based on thresholds in the general population: 7.2–7.5, > 7.5–11.5, and > 11.5 fL, respectively. Associations between baseline and time-dependent MPV with mortality were estimated using traditional and time-dependent Cox models in order to determine long-term and short-term exposure—mortality associations, respectively, using three adjustment levels: unadjusted, case-mix, and case-mix + laboratory models. Results In primary analyses, higher baseline and time-dependent MPV levels were associated with incrementally higher death risk in case-mix + laboratory analyses (reference: > 9.5–11.5 fL). In secondary analyses, high baseline and time-dependent MPV levels were associated with higher mortality, whereas low MPV was associated with lower death risk across all multivariable models (reference: normal MPV). Conclusions Hemodialysis patients with higher MPV have heightened mortality risk. Further studies are needed to determine the pathophysiologic basis for the higher risk, and if modification of MPV ameliorates mortality in this population.

AB - Background Higher mean platelet volume (MPV) is an indicator of larger, reactive platelets, and has been associated with a higher risk of thrombosis and cardiovascular events in the general population. Hemodialysis patients have a higher risk for cardiovascular death and predisposition to platelet dysfunction (thrombosis and bleeding diathesis), but the relationship between MPV and mortality in this population is unknown. Methods Among a 5-year cohort (1/2007–12/2011) of 149,118 incident hemodialysis patients from a large national dialysis organization, we examined the association between MPV and all-cause mortality. In primary analyses, we granularly analyzed MPV across five categories: 7.2–7.5, > 7.5–9.5, > 9.5–11.5, > 11.5–13.5, and > 13.5–15.0 fL. In secondary analyses, we examined MPV categorized as low, normal, and high based on thresholds in the general population: 7.2–7.5, > 7.5–11.5, and > 11.5 fL, respectively. Associations between baseline and time-dependent MPV with mortality were estimated using traditional and time-dependent Cox models in order to determine long-term and short-term exposure—mortality associations, respectively, using three adjustment levels: unadjusted, case-mix, and case-mix + laboratory models. Results In primary analyses, higher baseline and time-dependent MPV levels were associated with incrementally higher death risk in case-mix + laboratory analyses (reference: > 9.5–11.5 fL). In secondary analyses, high baseline and time-dependent MPV levels were associated with higher mortality, whereas low MPV was associated with lower death risk across all multivariable models (reference: normal MPV). Conclusions Hemodialysis patients with higher MPV have heightened mortality risk. Further studies are needed to determine the pathophysiologic basis for the higher risk, and if modification of MPV ameliorates mortality in this population.

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