Measures of coronary artery calcification and association with the metabolic syndrome and diabetes

Uzoma N. Ibebuogu, Naser Ahmadi, Fereshteh Hajsadeghi, Jessica Ramirez, Ferdinand Flores, Emily Young, Ambarish Gopal, Nathan D. Wong, Matthew J. Budoff

Research output: Contribution to journalArticle

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Abstract

The authors compared the metabolic syndrome status and Framingham 10-year coronary heart disease risk score (FRS) with the coronary artery calcification (CAC) in subclinical atherosclerosis. In all, 356 consecutive patients who underwent coronary artery calcium scanning were studied. Participants' metabolic syndrome status (by National Cholesterol Education Program Adult Treatment Panel III [NCEP ATP III] guidelines) and FRS were measured. The association between the metabolic syndrome, diabetes mellitus (DM), FRS, and CAC was analyzed by multivariable logistic regression analyses. These analyses were adjusted for demographics, age, sex, and conventional cardiovascular risk factors. The prevalence of significant CAC (CAC score ≥ 100) in those with DM, the metabolic syndrome, and neither condition was 64%, 43%, and 24%, respectively. The receiver operating characteristic C statistic for the prediction of significant CAC by the NCEP ATP III criteria for FRS, the metabolic syndrome, and DM was 0.61, 0.67, and 0.72, respectively, and increased significantly to 0.78 and 0.90 respectively for the metabolic syndrome and DM when added to the prediction models (P < .0001). This study suggests that the metabolic syndrome and DM are associated with increased risk of subclinical atherosclerosis. In addition, the presence of the metabolic syndrome or DM with increased FRS has incremental value over the FRS, DM, or the metabolic syndrome alone in predicting significant CAC.

Original languageEnglish (US)
Pages (from-to)6-11
Number of pages6
JournalJournal of the CardioMetabolic Syndrome
Volume4
Issue number1
DOIs
StatePublished - Mar 6 2009

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Coronary Vessels
Diabetes Mellitus
Atherosclerosis
Cholesterol
Education
ROC Curve
Coronary Disease
Logistic Models
Regression Analysis
Demography
Guidelines
Calcium
Therapeutics

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Cardiology and Cardiovascular Medicine

Cite this

Measures of coronary artery calcification and association with the metabolic syndrome and diabetes. / Ibebuogu, Uzoma N.; Ahmadi, Naser; Hajsadeghi, Fereshteh; Ramirez, Jessica; Flores, Ferdinand; Young, Emily; Gopal, Ambarish; Wong, Nathan D.; Budoff, Matthew J.

In: Journal of the CardioMetabolic Syndrome, Vol. 4, No. 1, 06.03.2009, p. 6-11.

Research output: Contribution to journalArticle

Ibebuogu, Uzoma N. ; Ahmadi, Naser ; Hajsadeghi, Fereshteh ; Ramirez, Jessica ; Flores, Ferdinand ; Young, Emily ; Gopal, Ambarish ; Wong, Nathan D. ; Budoff, Matthew J. / Measures of coronary artery calcification and association with the metabolic syndrome and diabetes. In: Journal of the CardioMetabolic Syndrome. 2009 ; Vol. 4, No. 1. pp. 6-11.
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