Mechanically stable surface-hydrophobilized chitosan nanofibrous barrier membranes for guided bone regeneration

Chaoxi Wu, Hengjie Su, Anastasios Karydis, Kenneth Anderson, Najib Ghadri, Shunqing Tang, Yifei Wang, Joel D. Bumgardner

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The use of chitosan based nanofiber membranes in guided bone regeneration (GBR) is limited by its uncontrolled swelling and mechanical instability in aqueous environments. This paper describes the significantly improved stability and properties of surface butyrylated chitosan nanofiber (BCSNF) membranes that greatly enhance their potential in GBR. The BCSNF membranes exhibited an overall degree of substitution of 1.61, an average diameter of 99.3 ±33.7 nm, and a 75% decrease in swelling with an approximate doubling in suture pull out strengths as compared to unmodified fibers in aqueous environment. In a five week phosphate-buffered saline-lysozyme degradation study, it was found that the remaining mass fraction of BCSNF membranes was 11.5% more than that of unmodified fibers. In vitro, the BCSNF membranes were found to support the adhesion and proliferation of fibroblasts and were cell occulusive. In vivo, the BCSNF membranes were found to significantly improve the regeneration of a rat calvarial critical size defect in a 12 week healing period and showed better barrier function than commercially available collagen membranes with little soft tissue penetration through the membranes. Taken together, these data provide strong scientific evidence for use of BCSNF membranes in GBR applications.

Original languageEnglish (US)
Article number015004
JournalBiomedical Materials (Bristol)
Volume13
Issue number1
DOIs
StatePublished - Jan 1 2018

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Chitosan
Bone
Nanofibers
Membranes
Swelling
Fibers
Fibroblasts
Muramidase
Collagen
Rats
Phosphates
Substitution reactions
Adhesion
Enzymes
Tissue
Degradation
Defects

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

Cite this

Mechanically stable surface-hydrophobilized chitosan nanofibrous barrier membranes for guided bone regeneration. / Wu, Chaoxi; Su, Hengjie; Karydis, Anastasios; Anderson, Kenneth; Ghadri, Najib; Tang, Shunqing; Wang, Yifei; Bumgardner, Joel D.

In: Biomedical Materials (Bristol), Vol. 13, No. 1, 015004, 01.01.2018.

Research output: Contribution to journalArticle

Wu, Chaoxi ; Su, Hengjie ; Karydis, Anastasios ; Anderson, Kenneth ; Ghadri, Najib ; Tang, Shunqing ; Wang, Yifei ; Bumgardner, Joel D. / Mechanically stable surface-hydrophobilized chitosan nanofibrous barrier membranes for guided bone regeneration. In: Biomedical Materials (Bristol). 2018 ; Vol. 13, No. 1.
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