Mechanism of action of sodium hypochlorite.

Carlos Estrela, Cyntia R.A. Estrela, Eduardo Luis Barbin, Júlio César E. Spanó, Melissa Marchesan, Jesus D. Pécora

Research output: Contribution to journalArticle

225 Citations (Scopus)

Abstract

The choice of an irrigating solution for use in infected root canals requires previous knowledge of the microorganisms responsible for the infectious process as well as the properties of different irrigating solutions. Complex internal anatomy, host defenses and microorganism virulence are important factors in the treatment of teeth with asymptomatic apical periodontitis. Irrigating solutions must have expressive antimicrobial action and tissue dissolution capacity. Sodium hypochlorite is the most used irrigating solution in endodontics, because its mechanism of action causes biosynthetic alterations in cellular metabolism and phospholipid destruction, formation of chloramines that interfere in cellular metabolism, oxidative action with irreversible enzymatic inactivation in bacteria, and lipid and fatty acid degradation. The aim of this work is to discuss the mechanism of action of sodium hypochlorite based on its antimicrobial and physico-chemical properties.

Original languageEnglish (US)
Pages (from-to)113-117
Number of pages5
JournalBrazilian dental journal
Volume13
Issue number2
DOIs
StatePublished - Jan 1 2002

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Sodium Hypochlorite
Chloramines
Periapical Periodontitis
Dental Pulp Cavity
Endodontics
Virulence Factors
Phospholipids
Anatomy
Tooth
Fatty Acids
Bacteria
Lipids

All Science Journal Classification (ASJC) codes

  • Dentistry(all)

Cite this

Estrela, C., Estrela, C. R. A., Barbin, E. L., Spanó, J. C. E., Marchesan, M., & Pécora, J. D. (2002). Mechanism of action of sodium hypochlorite. Brazilian dental journal, 13(2), 113-117. https://doi.org/10.1590/S0103-64402002000200007

Mechanism of action of sodium hypochlorite. / Estrela, Carlos; Estrela, Cyntia R.A.; Barbin, Eduardo Luis; Spanó, Júlio César E.; Marchesan, Melissa; Pécora, Jesus D.

In: Brazilian dental journal, Vol. 13, No. 2, 01.01.2002, p. 113-117.

Research output: Contribution to journalArticle

Estrela, C, Estrela, CRA, Barbin, EL, Spanó, JCE, Marchesan, M & Pécora, JD 2002, 'Mechanism of action of sodium hypochlorite.', Brazilian dental journal, vol. 13, no. 2, pp. 113-117. https://doi.org/10.1590/S0103-64402002000200007
Estrela C, Estrela CRA, Barbin EL, Spanó JCE, Marchesan M, Pécora JD. Mechanism of action of sodium hypochlorite. Brazilian dental journal. 2002 Jan 1;13(2):113-117. https://doi.org/10.1590/S0103-64402002000200007
Estrela, Carlos ; Estrela, Cyntia R.A. ; Barbin, Eduardo Luis ; Spanó, Júlio César E. ; Marchesan, Melissa ; Pécora, Jesus D. / Mechanism of action of sodium hypochlorite. In: Brazilian dental journal. 2002 ; Vol. 13, No. 2. pp. 113-117.
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