Mechanism of forelimb skin and skeletal muscle glucose uptake during Escherichia coli endotoxin shock in the dog.

Michael Karlstad, R. M. Raymond, T. E. Emerson

Research output: Contribution to journalArticle

Abstract

This study was undertaken to investigate mechanisms of increased glucose uptake by forelimb skin and skeletal muscle during endotoxin shock. Anesthetized mongrel dogs were used. Forelimbs were perfused at either natural or constant blood flow. Temperature of the isolated forelimb was maintained at core temperature. Shock was induced by an IV injection of 2 mg/kg Escherichia coli endotoxin. Forelimb skin and skeletal muscle glucose uptake increased by 30 minutes of shock and remained elevated in the natural flow study. In the constant flow study, glucose uptake by both skin and skeletal muscle was increased at 30 minutes of shock but thereafter returned to control. The natural flow forelimbs were ischemic and hypoxic during shock, whereas the constant flow forelimbs were neither ischemic not hypoxic. Progressive hypoglycemia developed in both endotoxin shock groups. These data support the hypothesis that the mechanism of increases in forelimb skin and skeletal muscle glucose uptake during endotoxin shock is related to local tissue hypoxia.

Original languageEnglish (US)
Pages (from-to)101-115
Number of pages15
JournalAdvances in shock research
Volume7
StatePublished - 1982
Externally publishedYes

Fingerprint

Forelimb
Shock
Skeletal Muscle
Dogs
Glucose
Skin
Endotoxins
Temperature
Escherichia coli endotoxin
Hypoglycemia
Injections

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Mechanism of forelimb skin and skeletal muscle glucose uptake during Escherichia coli endotoxin shock in the dog. / Karlstad, Michael; Raymond, R. M.; Emerson, T. E.

In: Advances in shock research, Vol. 7, 1982, p. 101-115.

Research output: Contribution to journalArticle

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