Mechanisms of roof plate formation in the vertebrate CNS

Viktor Chizhikov, Kathleen J. Millen

Research output: Contribution to journalReview article

60 Citations (Scopus)

Abstract

The roof plate is an embryonic organizing centre that occupies the dorsal midline of the vertebrate neural tube. During early CNS development, the roof plate produces secreted factors, which control the specification and differentiation of dorsal neuronal cell types. An appreciation of the signalling properties of the roof plate has prompted an enhanced interest in this important organizing centre, and several recent studies have begun to illuminate the molecular mechanisms of roof plate development.

Original languageEnglish (US)
Pages (from-to)808-812
Number of pages5
JournalNature Reviews Neuroscience
Volume5
Issue number10
DOIs
StatePublished - Jan 1 2004

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Neural Tube
Vertebrates

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Mechanisms of roof plate formation in the vertebrate CNS. / Chizhikov, Viktor; Millen, Kathleen J.

In: Nature Reviews Neuroscience, Vol. 5, No. 10, 01.01.2004, p. 808-812.

Research output: Contribution to journalReview article

Chizhikov, Viktor ; Millen, Kathleen J. / Mechanisms of roof plate formation in the vertebrate CNS. In: Nature Reviews Neuroscience. 2004 ; Vol. 5, No. 10. pp. 808-812.
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