Mechanisms underlying sleep-wake disturbances in alcoholism

Focus on the cholinergic pedunculopontine tegmentum

Clifford M. Knapp, Domenic A. Ciraulo, Subimal Datta

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Sleep-wake (S-W) disturbances are frequently associated with alcohol use disorders (AUD), occurring during periods of active drinking, withdrawal, and abstinence. These S-W disturbances can persist after months or even years of abstinence, suggesting that chronic alcohol consumption may have enduring negative effects on both homeostatic and circadian sleep processes. It is now generally accepted that S-W disturbances in alcohol-dependent individuals are a significant cause of relapse in drinking. Although significant progress has been made in identifying the socio-economic burden and health risks of alcohol addiction, the underlying neurobiological mechanisms that lead to S-W disorders in AUD are poorly understood. Marked progress has been made in understanding the basic neurobiological mechanisms of how different sleep stages are normally regulated. This review article in seeking to explain the neurobiological mechanisms underlying S-W disturbances associated with AUD, describes an evidence-based, easily testable, novel hypothesis that chronic alcohol consumption induces neuroadaptive changes in the cholinergic cell compartment of the pedunculopontine tegmentum (CCC-PPT). These changes include increases in N-methyl-d-aspartate (NMDA) and kainate receptor sensitivity and a decrease in gamma-aminobutyric acid (GABAB)-receptor sensitivity in the CCC-PPT. Together these changes are the primary pathophysiological mechanisms that underlie S-W disturbances in AUD. This review is targeted for both basic neuroscientists in alcohol addiction research and clinicians who are in search of new and more effective therapeutic interventions to treat and/or eliminate sleep disorders associated with AUD.

Original languageEnglish (US)
Pages (from-to)291-301
Number of pages11
JournalBehavioural Brain Research
Volume274
DOIs
StatePublished - Nov 1 2014

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Cholinergic Agents
Alcoholism
Sleep
Alcohols
Alcohol Drinking
Drinking
Kainic Acid Receptors
GABA Receptors
Sleep Stages
Economics
Recurrence
Health
Research
Sleep Wake Disorders

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience

Cite this

Mechanisms underlying sleep-wake disturbances in alcoholism : Focus on the cholinergic pedunculopontine tegmentum. / Knapp, Clifford M.; Ciraulo, Domenic A.; Datta, Subimal.

In: Behavioural Brain Research, Vol. 274, 01.11.2014, p. 291-301.

Research output: Contribution to journalReview article

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