Mediterranean diet and risk of dementia

Apostolos Safouris, Georgios Tsivgoulis, Theodoros N. Sergentanis, Theodora Psaltopoulou

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Dementia is a major global health challenge, as its burden on society will increase with population aging. Given the lack of effective pharmaceutical treatment for common types of dementia including Alzheimer’s disease and vascular dementia, research interest in lifestyle modifications that could prevent, postpone the clinical syndrome or decelerate progression of dementia is growing. Among the various dietary patterns that were tested for their effects on cognition, the traditional Mediterranean diet (MeDi) has shown promising results. This review aims to summarize the epidemiological evidence on the effects of MeDi on the prevention of dementia, presenting data from cross-sectional as well as longitudinal observational studies conducted both in Mediterranean and non-Mediterranean countries. These findings have been also reproduced in the context of one recent randomizedcontrolled clinical trial. Postulated mechanisms of action that may account for the potential protective effect of MeDi on cognitive impairment will be briefly discussed. Despite the fact that the link between MeDi and cognitive decline has been only explored for less than a decade, data on efficacy is rapidly increasing and allows optimism that MeDi could emerge as an alternative prophylactic treatment for dementia.

Original languageEnglish (US)
Pages (from-to)736-744
Number of pages9
JournalCurrent Alzheimer Research
Volume12
Issue number8
DOIs
StatePublished - Sep 1 2015

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Mediterranean Diet
Dementia
Alzheimer Disease
Vascular Dementia
Cognition
Observational Studies
Longitudinal Studies
Life Style
Clinical Trials
Therapeutics
Research
Pharmaceutical Preparations
Population

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Mediterranean diet and risk of dementia. / Safouris, Apostolos; Tsivgoulis, Georgios; Sergentanis, Theodoros N.; Psaltopoulou, Theodora.

In: Current Alzheimer Research, Vol. 12, No. 8, 01.09.2015, p. 736-744.

Research output: Contribution to journalArticle

Safouris, A, Tsivgoulis, G, Sergentanis, TN & Psaltopoulou, T 2015, 'Mediterranean diet and risk of dementia', Current Alzheimer Research, vol. 12, no. 8, pp. 736-744. https://doi.org/10.2174/1567205012666150710114430
Safouris, Apostolos ; Tsivgoulis, Georgios ; Sergentanis, Theodoros N. ; Psaltopoulou, Theodora. / Mediterranean diet and risk of dementia. In: Current Alzheimer Research. 2015 ; Vol. 12, No. 8. pp. 736-744.
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