Medulloblastoma metastatic to the suprasellar region at diagnosis

A report of six cases with clinicopathologic correlation

Kathleen J. Helton, Amar Gajjar, D. Ashley Hill, Frederick Boop, Larry E. Kun, James W. Langston

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The presence of metastatic disease in patients newly diagnosed with medulloblastoma remains one of the most important prognostic factors that determines event-free survival. In the present study, anatomic distribution and the signal characteristics and enhancement patterns of subtle anterior third ventricular recess metastases were compared with those of the original tumor; medical records were reviewed for clinical presentation, surgical stage, treatment and long-term outcomes. All foci were clinically occult; 5 out of 6 had negative cerebrospinal fluid cytology, and in 4 out of 6, the only evidence of metastatic disease was documented suprasellar disease that resolved or significantly improved following irradiation and chemotherapy. Histologically, 3 of the 6 patients had tumors with large cell/anaplastic features, a significant increase compared to the expected incidence of 4-8.8%. Patients with tumors that show large cell/anaplastic features may be at higher risk for early metastatic involvement of this unusual site.

Original languageEnglish (US)
Pages (from-to)111-117
Number of pages7
JournalPediatric Neurosurgery
Volume37
Issue number3
DOIs
StatePublished - Sep 14 2002

Fingerprint

Medulloblastoma
Neoplasms
Disease-Free Survival
Medical Records
Cell Biology
Cerebrospinal Fluid
Neoplasm Metastasis
Drug Therapy
Incidence
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

Cite this

Medulloblastoma metastatic to the suprasellar region at diagnosis : A report of six cases with clinicopathologic correlation. / Helton, Kathleen J.; Gajjar, Amar; Hill, D. Ashley; Boop, Frederick; Kun, Larry E.; Langston, James W.

In: Pediatric Neurosurgery, Vol. 37, No. 3, 14.09.2002, p. 111-117.

Research output: Contribution to journalArticle

Helton, Kathleen J. ; Gajjar, Amar ; Hill, D. Ashley ; Boop, Frederick ; Kun, Larry E. ; Langston, James W. / Medulloblastoma metastatic to the suprasellar region at diagnosis : A report of six cases with clinicopathologic correlation. In: Pediatric Neurosurgery. 2002 ; Vol. 37, No. 3. pp. 111-117.
@article{806ceb76b52a4c079840f144134ece3c,
title = "Medulloblastoma metastatic to the suprasellar region at diagnosis: A report of six cases with clinicopathologic correlation",
abstract = "The presence of metastatic disease in patients newly diagnosed with medulloblastoma remains one of the most important prognostic factors that determines event-free survival. In the present study, anatomic distribution and the signal characteristics and enhancement patterns of subtle anterior third ventricular recess metastases were compared with those of the original tumor; medical records were reviewed for clinical presentation, surgical stage, treatment and long-term outcomes. All foci were clinically occult; 5 out of 6 had negative cerebrospinal fluid cytology, and in 4 out of 6, the only evidence of metastatic disease was documented suprasellar disease that resolved or significantly improved following irradiation and chemotherapy. Histologically, 3 of the 6 patients had tumors with large cell/anaplastic features, a significant increase compared to the expected incidence of 4-8.8{\%}. Patients with tumors that show large cell/anaplastic features may be at higher risk for early metastatic involvement of this unusual site.",
author = "Helton, {Kathleen J.} and Amar Gajjar and Hill, {D. Ashley} and Frederick Boop and Kun, {Larry E.} and Langston, {James W.}",
year = "2002",
month = "9",
day = "14",
doi = "10.1159/000064392",
language = "English (US)",
volume = "37",
pages = "111--117",
journal = "Pediatric Neurosurgery",
issn = "1016-2291",
publisher = "S. Karger AG",
number = "3",

}

TY - JOUR

T1 - Medulloblastoma metastatic to the suprasellar region at diagnosis

T2 - A report of six cases with clinicopathologic correlation

AU - Helton, Kathleen J.

AU - Gajjar, Amar

AU - Hill, D. Ashley

AU - Boop, Frederick

AU - Kun, Larry E.

AU - Langston, James W.

PY - 2002/9/14

Y1 - 2002/9/14

N2 - The presence of metastatic disease in patients newly diagnosed with medulloblastoma remains one of the most important prognostic factors that determines event-free survival. In the present study, anatomic distribution and the signal characteristics and enhancement patterns of subtle anterior third ventricular recess metastases were compared with those of the original tumor; medical records were reviewed for clinical presentation, surgical stage, treatment and long-term outcomes. All foci were clinically occult; 5 out of 6 had negative cerebrospinal fluid cytology, and in 4 out of 6, the only evidence of metastatic disease was documented suprasellar disease that resolved or significantly improved following irradiation and chemotherapy. Histologically, 3 of the 6 patients had tumors with large cell/anaplastic features, a significant increase compared to the expected incidence of 4-8.8%. Patients with tumors that show large cell/anaplastic features may be at higher risk for early metastatic involvement of this unusual site.

AB - The presence of metastatic disease in patients newly diagnosed with medulloblastoma remains one of the most important prognostic factors that determines event-free survival. In the present study, anatomic distribution and the signal characteristics and enhancement patterns of subtle anterior third ventricular recess metastases were compared with those of the original tumor; medical records were reviewed for clinical presentation, surgical stage, treatment and long-term outcomes. All foci were clinically occult; 5 out of 6 had negative cerebrospinal fluid cytology, and in 4 out of 6, the only evidence of metastatic disease was documented suprasellar disease that resolved or significantly improved following irradiation and chemotherapy. Histologically, 3 of the 6 patients had tumors with large cell/anaplastic features, a significant increase compared to the expected incidence of 4-8.8%. Patients with tumors that show large cell/anaplastic features may be at higher risk for early metastatic involvement of this unusual site.

UR - http://www.scopus.com/inward/record.url?scp=0036025180&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036025180&partnerID=8YFLogxK

U2 - 10.1159/000064392

DO - 10.1159/000064392

M3 - Article

VL - 37

SP - 111

EP - 117

JO - Pediatric Neurosurgery

JF - Pediatric Neurosurgery

SN - 1016-2291

IS - 3

ER -