Membrane lipids and modulation of vascular smooth muscle Ion channels

Alejandro Dopico, Anna Bukiya, Guruprasad Kuntamallappanavar

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

In vascular smooth muscle (VSM), lipids regulate the function of many cellular proteins, including ion channels. Lipids can directly target ion channels or regulate ion channels indirectly, that is, through interactions with cell signalling molecules that eventually target the ion channel. We summarize current knowledge on VSM ion channel regulation by lipids, whether lipids are originated in the smooth muscle itself, vascular endothelium, or paracrine or circulation sources, with a focus on possible direct interaction between lipid molecules and the proteins that constitute the VSM ion channel complex. We also describe the contribution of such lipid- VSM ion channel interaction to VSM physiology and pathophysiology. However, more than one mechanism or type of interaction may be involved in lipid-induced regulation of VSM ion channels and some mechanisms are not mutually exclusive, which adds signifi cant complexity to the fi eld. Understanding the mechanisms that underlie lipid modulation of VSM ion channels, however, is necessary for developing novel therapeutic approaches to improve vascular function and prevent or counteract widespread cardio/cerebrovascular disorders.

Original languageEnglish (US)
Title of host publicationVascular Ion Channels in Physiology and Disease
PublisherSpringer International Publishing
Pages349-380
Number of pages32
ISBN (Electronic)9783319296357
ISBN (Print)9783319296333
DOIs
StatePublished - Jan 1 2016

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Membrane Lipids
Ion Channels
Vascular Smooth Muscle
Muscle
Modulation
Lipids
Cell signaling
Cerebrovascular Disorders
Molecules
Physiology
Vascular Endothelium
Cell Communication
Smooth Muscle
Blood Vessels
Proteins

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Dopico, A., Bukiya, A., & Kuntamallappanavar, G. (2016). Membrane lipids and modulation of vascular smooth muscle Ion channels. In Vascular Ion Channels in Physiology and Disease (pp. 349-380). Springer International Publishing. https://doi.org/10.1007/978-3-319-29635-7_16

Membrane lipids and modulation of vascular smooth muscle Ion channels. / Dopico, Alejandro; Bukiya, Anna; Kuntamallappanavar, Guruprasad.

Vascular Ion Channels in Physiology and Disease. Springer International Publishing, 2016. p. 349-380.

Research output: Chapter in Book/Report/Conference proceedingChapter

Dopico, A, Bukiya, A & Kuntamallappanavar, G 2016, Membrane lipids and modulation of vascular smooth muscle Ion channels. in Vascular Ion Channels in Physiology and Disease. Springer International Publishing, pp. 349-380. https://doi.org/10.1007/978-3-319-29635-7_16
Dopico A, Bukiya A, Kuntamallappanavar G. Membrane lipids and modulation of vascular smooth muscle Ion channels. In Vascular Ion Channels in Physiology and Disease. Springer International Publishing. 2016. p. 349-380 https://doi.org/10.1007/978-3-319-29635-7_16
Dopico, Alejandro ; Bukiya, Anna ; Kuntamallappanavar, Guruprasad. / Membrane lipids and modulation of vascular smooth muscle Ion channels. Vascular Ion Channels in Physiology and Disease. Springer International Publishing, 2016. pp. 349-380
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