Membranous glomerulonephritis induced in the pig by antibody to angiotensin-converting enzyme: Considerations on its relevance to the pathogenesis of human idiopathic: Membranous glomerulonephritis

Shoichi Maruyama, Edward Cantu, Cesare Demartino, Adrian Vladutiu, Peter R.B. Caldwell, Catherine Y. Wang, Vivette D'Agati, Gabriel Godman, David Stern, Giuseppe Andres

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

In the course of studies on the humoral consequences of swine to primate xenotransplantation, the investigators induced formation of glomerular subepithelial immune deposits and tubular lesions in pigs injected with heterologous antibody to angiotensin-converting enzyme. This study describes the morphology of the lesions, discusses their mechanism, explains their relevance for understanding the pathogenesis of human idiopathic membranous glomerulonephritis, and proposes future directions for investigations.

Original languageEnglish (US)
Pages (from-to)2102-2108
Number of pages7
JournalJournal of the American Society of Nephrology
Volume10
Issue number10
StatePublished - Oct 1 1999

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Membranous Glomerulonephritis
Peptidyl-Dipeptidase A
Swine
Heterophile Antibodies
Heterologous Transplantation
Antibodies
Primates
Research Personnel
Direction compound

All Science Journal Classification (ASJC) codes

  • Nephrology

Cite this

Membranous glomerulonephritis induced in the pig by antibody to angiotensin-converting enzyme : Considerations on its relevance to the pathogenesis of human idiopathic: Membranous glomerulonephritis. / Maruyama, Shoichi; Cantu, Edward; Demartino, Cesare; Vladutiu, Adrian; Caldwell, Peter R.B.; Wang, Catherine Y.; D'Agati, Vivette; Godman, Gabriel; Stern, David; Andres, Giuseppe.

In: Journal of the American Society of Nephrology, Vol. 10, No. 10, 01.10.1999, p. 2102-2108.

Research output: Contribution to journalArticle

Maruyama, Shoichi ; Cantu, Edward ; Demartino, Cesare ; Vladutiu, Adrian ; Caldwell, Peter R.B. ; Wang, Catherine Y. ; D'Agati, Vivette ; Godman, Gabriel ; Stern, David ; Andres, Giuseppe. / Membranous glomerulonephritis induced in the pig by antibody to angiotensin-converting enzyme : Considerations on its relevance to the pathogenesis of human idiopathic: Membranous glomerulonephritis. In: Journal of the American Society of Nephrology. 1999 ; Vol. 10, No. 10. pp. 2102-2108.
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