Meningiomas in children: MR and histopathologic findings

C. M. Glasier, M. M. Husain, W. Chadduck, Frederick Boop

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

PURPOSE: To present the MR and histopathologic findings in five children with meningiomas. METHODS: Five children aged 3 months to 16 years with pathologically proved meningiomas underwent preoperative contrast enhanced MR. Tissue in four patients was sent for chromosomal analysis in addition to routine histopathologic studies. RESULTS: All five tumors were extra-axial, two supratentorial and three in the posterior fossa. MR showed variable signal intensity on precontrast T1-weighted images. All of the tumors were hyperintense on proton density- and T2-weighted images and showed intense contrast enhancement. Histopathologic analysis showed two meningotheliomatous, one transitional, one chordoid, and one hemangiopericytic variant of meningioma. Chromosomal analysis showed deletions involving chromosome 22 in two of four tumors studied. CONCLUSION: Meningiomas in children have a higher incidence of posterior fossa location and different histologic types than seen in adults. MR showed the tumors in our patients to be extra-axial, hyperintense on proton density- and T2-weighted images with intense enhancement on postcontrast T1-weighted images. Chromosomal aberrations were noted in two patients.

Original languageEnglish (US)
Pages (from-to)237-241
Number of pages5
JournalAmerican Journal of Neuroradiology
Volume14
Issue number1
StatePublished - Jan 1 1993

Fingerprint

Meningioma
Protons
Neoplasms
Notochord
Chromosomes, Human, Pair 22
Chromosome Aberrations
Incidence

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

Cite this

Glasier, C. M., Husain, M. M., Chadduck, W., & Boop, F. (1993). Meningiomas in children: MR and histopathologic findings. American Journal of Neuroradiology, 14(1), 237-241.

Meningiomas in children : MR and histopathologic findings. / Glasier, C. M.; Husain, M. M.; Chadduck, W.; Boop, Frederick.

In: American Journal of Neuroradiology, Vol. 14, No. 1, 01.01.1993, p. 237-241.

Research output: Contribution to journalArticle

Glasier, CM, Husain, MM, Chadduck, W & Boop, F 1993, 'Meningiomas in children: MR and histopathologic findings', American Journal of Neuroradiology, vol. 14, no. 1, pp. 237-241.
Glasier, C. M. ; Husain, M. M. ; Chadduck, W. ; Boop, Frederick. / Meningiomas in children : MR and histopathologic findings. In: American Journal of Neuroradiology. 1993 ; Vol. 14, No. 1. pp. 237-241.
@article{de573cfcb2d34be0a0fd9cfccd68816b,
title = "Meningiomas in children: MR and histopathologic findings",
abstract = "PURPOSE: To present the MR and histopathologic findings in five children with meningiomas. METHODS: Five children aged 3 months to 16 years with pathologically proved meningiomas underwent preoperative contrast enhanced MR. Tissue in four patients was sent for chromosomal analysis in addition to routine histopathologic studies. RESULTS: All five tumors were extra-axial, two supratentorial and three in the posterior fossa. MR showed variable signal intensity on precontrast T1-weighted images. All of the tumors were hyperintense on proton density- and T2-weighted images and showed intense contrast enhancement. Histopathologic analysis showed two meningotheliomatous, one transitional, one chordoid, and one hemangiopericytic variant of meningioma. Chromosomal analysis showed deletions involving chromosome 22 in two of four tumors studied. CONCLUSION: Meningiomas in children have a higher incidence of posterior fossa location and different histologic types than seen in adults. MR showed the tumors in our patients to be extra-axial, hyperintense on proton density- and T2-weighted images with intense enhancement on postcontrast T1-weighted images. Chromosomal aberrations were noted in two patients.",
author = "Glasier, {C. M.} and Husain, {M. M.} and W. Chadduck and Frederick Boop",
year = "1993",
month = "1",
day = "1",
language = "English (US)",
volume = "14",
pages = "237--241",
journal = "American Journal of Neuroradiology",
issn = "0195-6108",
publisher = "American Society of Neuroradiology",
number = "1",

}

TY - JOUR

T1 - Meningiomas in children

T2 - MR and histopathologic findings

AU - Glasier, C. M.

AU - Husain, M. M.

AU - Chadduck, W.

AU - Boop, Frederick

PY - 1993/1/1

Y1 - 1993/1/1

N2 - PURPOSE: To present the MR and histopathologic findings in five children with meningiomas. METHODS: Five children aged 3 months to 16 years with pathologically proved meningiomas underwent preoperative contrast enhanced MR. Tissue in four patients was sent for chromosomal analysis in addition to routine histopathologic studies. RESULTS: All five tumors were extra-axial, two supratentorial and three in the posterior fossa. MR showed variable signal intensity on precontrast T1-weighted images. All of the tumors were hyperintense on proton density- and T2-weighted images and showed intense contrast enhancement. Histopathologic analysis showed two meningotheliomatous, one transitional, one chordoid, and one hemangiopericytic variant of meningioma. Chromosomal analysis showed deletions involving chromosome 22 in two of four tumors studied. CONCLUSION: Meningiomas in children have a higher incidence of posterior fossa location and different histologic types than seen in adults. MR showed the tumors in our patients to be extra-axial, hyperintense on proton density- and T2-weighted images with intense enhancement on postcontrast T1-weighted images. Chromosomal aberrations were noted in two patients.

AB - PURPOSE: To present the MR and histopathologic findings in five children with meningiomas. METHODS: Five children aged 3 months to 16 years with pathologically proved meningiomas underwent preoperative contrast enhanced MR. Tissue in four patients was sent for chromosomal analysis in addition to routine histopathologic studies. RESULTS: All five tumors were extra-axial, two supratentorial and three in the posterior fossa. MR showed variable signal intensity on precontrast T1-weighted images. All of the tumors were hyperintense on proton density- and T2-weighted images and showed intense contrast enhancement. Histopathologic analysis showed two meningotheliomatous, one transitional, one chordoid, and one hemangiopericytic variant of meningioma. Chromosomal analysis showed deletions involving chromosome 22 in two of four tumors studied. CONCLUSION: Meningiomas in children have a higher incidence of posterior fossa location and different histologic types than seen in adults. MR showed the tumors in our patients to be extra-axial, hyperintense on proton density- and T2-weighted images with intense enhancement on postcontrast T1-weighted images. Chromosomal aberrations were noted in two patients.

UR - http://www.scopus.com/inward/record.url?scp=0027398591&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027398591&partnerID=8YFLogxK

M3 - Article

C2 - 8427097

AN - SCOPUS:0027398591

VL - 14

SP - 237

EP - 241

JO - American Journal of Neuroradiology

JF - American Journal of Neuroradiology

SN - 0195-6108

IS - 1

ER -