Messengers of Tolerance

Sai Vineela Bontha, Angela Fernandez-Piñeros, Daniel Maluf, Valeria Mas

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

The use of immunosuppressant drugs after organ transplantation has brought great success in the field of organ transplantation with respect to short-term outcome. However, major challenges such (i.e., limited improvement of long-term survival, immunosuppressant toxicity, infections and carcinoma), demand alternate treatment approaches that minimizes the use of immunosuppressants. Interestingly, few studies have identified groups of transplant patients who developed operational tolerance and thereby keep their allograft without complications in absence of immunosuppressants. These rare groups of patients are of particular interest as study subjects for understanding mechanisms of graft tolerance that could be leveraged in future for inducing tolerance and for understanding mechanisms involved in improving long-term allograft outcomes. Also, biomarkers from these studies could benefit the larger transplant population by their application in immunosuppressant tailoring and identification of tolerant patients among patients with stably functioning allografts. This review compiles several gene expression studies performed in samples from tolerant patients in different solid organ transplantations to identify key genes and associated molecular pathways relevant to tolerance. This review is aimed at putting forth all this important work done thus far and to identify research gaps that need to be filled, in order to achieve the greater purpose of these studies.

Original languageEnglish (US)
Pages (from-to)362-372
Number of pages11
JournalHuman Immunology
Volume79
Issue number5
DOIs
StatePublished - May 1 2018
Externally publishedYes

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Immunosuppressive Agents
Organ Transplantation
Allografts
Transplantation Tolerance
Transplants
Biomarkers
Carcinoma
Gene Expression
Survival
Infection
Research
Pharmaceutical Preparations
Population
Genes
Therapeutics

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Messengers of Tolerance. / Bontha, Sai Vineela; Fernandez-Piñeros, Angela; Maluf, Daniel; Mas, Valeria.

In: Human Immunology, Vol. 79, No. 5, 01.05.2018, p. 362-372.

Research output: Contribution to journalReview article

Bontha, SV, Fernandez-Piñeros, A, Maluf, D & Mas, V 2018, 'Messengers of Tolerance', Human Immunology, vol. 79, no. 5, pp. 362-372. https://doi.org/10.1016/j.humimm.2018.01.008
Bontha, Sai Vineela ; Fernandez-Piñeros, Angela ; Maluf, Daniel ; Mas, Valeria. / Messengers of Tolerance. In: Human Immunology. 2018 ; Vol. 79, No. 5. pp. 362-372.
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