Meta-analysis of univariate P-values

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We propose a new meta-analysis method to pool univariate p-values across independent studies and we compare our method with that of Fisher, Stouffer, and George through simulations and identify sub-spaces where each of these methods are optimal and propose a strategy to choose the best meta-analysis method under different sub-spaces. We compare these meta-analysis approaches using p-values from periodicity tests of 4,940 S. Pombe genes from 10 independent time-course experiments and show that our new approach ranks the periodic, conserved, and cycling genes much higher, and detects at least as many genes among the top 1,000 genes, compared to other methods.

Original languageEnglish (US)
Pages (from-to)1257-1265
Number of pages9
JournalCommunications in Statistics: Simulation and Computation
Volume46
Issue number2
DOIs
StatePublished - Feb 7 2017

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Univariate
Genes
Gene
p-Value
Subspace
Cycling
Periodicity
Choose
Experiments
Experiment
Simulation

All Science Journal Classification (ASJC) codes

  • Statistics and Probability
  • Modeling and Simulation

Cite this

Meta-analysis of univariate P-values. / Kocak, Mehmet.

In: Communications in Statistics: Simulation and Computation, Vol. 46, No. 2, 07.02.2017, p. 1257-1265.

Research output: Contribution to journalArticle

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