Metabolic syndrome, prediabetes and the science of primary prevention

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

This review provides an update on the metabolic syndrome and prediabetes. Compared to the downstream disorders, namely type 2 diabetes and cardiovascular disease (including coronary artery disease, cerebrovascular disease and peripheral vascular disease), prediabetes and the metabolic syndrome represent intermediate cardiometabolic states. The generally accepted working definitions, epidemiology, pathophysiology and clinical relevance of these intermediate conditions are discussed. Importantly, the review focuses on evidence-based strategies for preventing the cardiometabolic sequelae associated with prediabetes and the metabolic syndrome. The importance of lifestyle modification in the primary prevention of the metabolic syndrome and prediabetes is emphasized, and the interaction between genetics and lifestyle intervention in predicting outcomes is presented. In addition to discussing the evidence from landmark clinical trials, we identify methods for translating the success achieved in clinical trials to the community with regard to the prevention of diabetes and cardiometabolic risk. Future research needs are also highlighted. The overall goal is to foster an increased understanding of the prominent role of primary prevention in stemming the tide of cardiometabolic disorders in the society.

Original languageEnglish (US)
Pages (from-to)129-145
Number of pages17
JournalMinerva Endocrinologica
Volume36
Issue number2
StatePublished - Jun 1 2011

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Prediabetic State
Primary Prevention
Life Style
Clinical Trials
Cerebrovascular Disorders
Genetic Engineering
Peripheral Vascular Diseases
Type 2 Diabetes Mellitus
Coronary Artery Disease
Epidemiology
Cardiovascular Diseases

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Metabolic syndrome, prediabetes and the science of primary prevention. / Nyenwe, Ebenezer; Dagogo-Jack, Samuel.

In: Minerva Endocrinologica, Vol. 36, No. 2, 01.06.2011, p. 129-145.

Research output: Contribution to journalReview article

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