Metallofullerene drug design

L. J. Wilson, D. W. Cagle, T. P. Thrash, Stephen Kennel, S. Mirzadeh, J. M. Alford, G. J. Ehrhardt

Research output: Contribution to journalArticle

156 Citations (Scopus)

Abstract

Endohedral lanthanide metallofullerenes are new molecules that may have useful medicinal properties. In particular, endohedral holmium metallofullerenes have been utilized in a model metallofullerene radiotracer study. The 165Ho metallofullerenes were chemically functionalized to impart water solubility and then neutron activated to 166Ho in order to determine their biodistribution and metabolism properties. The results have been evaluated for potential applications of lanthanide metallofullerenes as new diagnostic or therapeutic radiopharmaceuticals. Use of metallofullerenes in conventional diagnostic radiology (MRI contrast and X-ray imaging agents) has also been considered. (C) 1999 Elsevier Science S.A.

Original languageEnglish (US)
Pages (from-to)199-207
Number of pages9
JournalCoordination Chemistry Reviews
Volume190-192
DOIs
StatePublished - Dec 1 1999

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Lanthanoid Series Elements
Rare earth elements
drugs
Holmium
Radiology
holmium
Radiopharmaceuticals
radiology
metabolism
Metabolism
Pharmaceutical Preparations
Magnetic resonance imaging
Neutrons
solubility
Solubility
Imaging techniques
neutrons
X rays
Molecules
Water

All Science Journal Classification (ASJC) codes

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

Cite this

Wilson, L. J., Cagle, D. W., Thrash, T. P., Kennel, S., Mirzadeh, S., Alford, J. M., & Ehrhardt, G. J. (1999). Metallofullerene drug design. Coordination Chemistry Reviews, 190-192, 199-207. https://doi.org/10.1016/S0010-8545(99)00080-6

Metallofullerene drug design. / Wilson, L. J.; Cagle, D. W.; Thrash, T. P.; Kennel, Stephen; Mirzadeh, S.; Alford, J. M.; Ehrhardt, G. J.

In: Coordination Chemistry Reviews, Vol. 190-192, 01.12.1999, p. 199-207.

Research output: Contribution to journalArticle

Wilson, LJ, Cagle, DW, Thrash, TP, Kennel, S, Mirzadeh, S, Alford, JM & Ehrhardt, GJ 1999, 'Metallofullerene drug design', Coordination Chemistry Reviews, vol. 190-192, pp. 199-207. https://doi.org/10.1016/S0010-8545(99)00080-6
Wilson LJ, Cagle DW, Thrash TP, Kennel S, Mirzadeh S, Alford JM et al. Metallofullerene drug design. Coordination Chemistry Reviews. 1999 Dec 1;190-192:199-207. https://doi.org/10.1016/S0010-8545(99)00080-6
Wilson, L. J. ; Cagle, D. W. ; Thrash, T. P. ; Kennel, Stephen ; Mirzadeh, S. ; Alford, J. M. ; Ehrhardt, G. J. / Metallofullerene drug design. In: Coordination Chemistry Reviews. 1999 ; Vol. 190-192. pp. 199-207.
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