Mice perceive synergistic umami mixtures as tasting sweet

Louis N. Saites, Zachary Goldsmith, Jaron Densky, Vivian A. Guedes, John Boughter

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Previous electrophysiological investigation shows that combinations of compounds classified by humans as umami-tasting, such as glutamate salts and 5'-ribonucleotides, elicit synergistic responses in neurons throughout the rodent taste system and produce a pattern that resembles responses to sweet compounds. The current study tested the hypothesis that a synergistic mixture of monopotassium glutamate (MPG) and inositol monophosphate (IMP) possesses perceptual similarity to sucrose in mice. We estimated behavioral similarity among these tastants and the individual umami compounds using a series of conditioned taste aversion (CTA) tests, a procedure that measures whether a CTA formed to one stimulus generalizes to another. Our primary finding was that a CTA to a synergistic mixture of MPG + IMP generalizes to sucrose, and vice-versa. This indicates umami synergistic mixtures are perceived as having a sweet, or at least sucroselike, taste to mice. Considering other recent studies, our data argue strongly in favor of multiple receptor mechanisms for umami detection, and complexity in taste perception models for rodents.

Original languageEnglish (US)
Pages (from-to)295-303
Number of pages9
JournalChemical Senses
Volume40
Issue number5
DOIs
StatePublished - Jan 1 2015

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Glutamic Acid
Inositol
Sucrose
Rodentia
Taste Perception
Ribonucleotides
Salts
Neurons

All Science Journal Classification (ASJC) codes

  • Physiology
  • Sensory Systems
  • Physiology (medical)
  • Behavioral Neuroscience

Cite this

Saites, L. N., Goldsmith, Z., Densky, J., Guedes, V. A., & Boughter, J. (2015). Mice perceive synergistic umami mixtures as tasting sweet. Chemical Senses, 40(5), 295-303. https://doi.org/10.1093/chemse/bjv010

Mice perceive synergistic umami mixtures as tasting sweet. / Saites, Louis N.; Goldsmith, Zachary; Densky, Jaron; Guedes, Vivian A.; Boughter, John.

In: Chemical Senses, Vol. 40, No. 5, 01.01.2015, p. 295-303.

Research output: Contribution to journalArticle

Saites, LN, Goldsmith, Z, Densky, J, Guedes, VA & Boughter, J 2015, 'Mice perceive synergistic umami mixtures as tasting sweet', Chemical Senses, vol. 40, no. 5, pp. 295-303. https://doi.org/10.1093/chemse/bjv010
Saites, Louis N. ; Goldsmith, Zachary ; Densky, Jaron ; Guedes, Vivian A. ; Boughter, John. / Mice perceive synergistic umami mixtures as tasting sweet. In: Chemical Senses. 2015 ; Vol. 40, No. 5. pp. 295-303.
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