Microarrays in gastrointestinal cancer: Is personalized prediction of response to chemotherapy at hand?

Eric H. Jensen, James M. McLoughlin, Timothy J. Yeatman

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

PURPOSE OF REVIEW: Molecular profiling has proven to be an invaluable tool in cancer research. Although only in its infancy, microarray technology and gene arrays have led to substantial advances in tumor identification, staging and prediction of response. This review outlines some of the more recent advances in the use of microarrays as a novel means to advance the standard of care for patients with gastrointestinal cancers. RECENT FINDINGS: Recent investigations have shown that gene expression profiles can be used to identify, stage, and guide therapeutic intervention in many gastrointestinal cancers. In cases of unknown primary disease, genetic fingerprints can be used to define the origin of the tumor in the majority of cases. Similarly, gene expression has been shown to allow for more accurate staging of patients with a variety of tumor types. Perhaps most exciting is early data that support the potential for microarray to guide therapeutic intervention by providing specific gene fingerprints which correlate with sensitivity to specific chemotherapy, biologic therapy, or other cancer treatments. SUMMARY: Gene microarrays have become a powerful resource in cancer investigations. Individualized cancer care based on specific gene profiles is on the horizon for patients with gastrointestinal cancers.

Original languageEnglish (US)
Pages (from-to)374-380
Number of pages7
JournalCurrent Opinion in Oncology
Volume18
Issue number4
DOIs
StatePublished - Jul 1 2006

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Gastrointestinal Neoplasms
Hand
Drug Therapy
Neoplasms
Dermatoglyphics
Genes
Inborn Genetic Diseases
Biological Therapy
Neoplasm Staging
Standard of Care
Transcriptome
Therapeutics
Technology
Gene Expression
Research

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Microarrays in gastrointestinal cancer : Is personalized prediction of response to chemotherapy at hand? / Jensen, Eric H.; McLoughlin, James M.; Yeatman, Timothy J.

In: Current Opinion in Oncology, Vol. 18, No. 4, 01.07.2006, p. 374-380.

Research output: Contribution to journalReview article

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