Microdosimetric study for interpretation of outcomes from boron neutron capture therapy clinical trials

T. L. Nichols, L. F. Miller, George Kabalka, Tina Dudney

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Boron neutron capture therapy is a brachyradiotherapy utilizing the 10B(n,α)7Li reaction that has been used to treat glioblastoma multiforme (GBM), melanoma and colon carcinoma liver metastases. GBM clinical trials resulted in modestly improved life expectancies compared with conventional therapies. Early results trials focused on malignant melanoma and colon carcinoma provide dramatically better results. Macrodosimetry cannot explain these apparent differences. The dichotomy can only be understood using microdosimetry techniques. A computer program has been created to provide an improved tissue model. This model permits the dose in each cell's cytoplasm, nucleus, and the interstitium to be calculated for ellipsoidal cells placed in either random or ordered locations. The nuclei can be centered or eccentric. The new model provides insight into the micro level for differences in the trials. The differences arise from the tissue's cellular geometry and the effects of neighboring cells. These results help to explain the observed clinical outcomes.

Original languageEnglish (US)
Pages (from-to)645-647
Number of pages3
JournalRadiation Protection Dosimetry
Volume126
Issue number1-4
DOIs
StatePublished - Dec 1 2007

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Boron Neutron Capture Therapy
Glioblastoma
Melanoma
therapy
Colon
boron
Outcome Assessment (Health Care)
Clinical Trials
Carcinoma
neutrons
Life Expectancy
cancer
cells
Cell Nucleus
dichotomies
Cytoplasm
nuclei
Software
cytoplasm
eccentrics

All Science Journal Classification (ASJC) codes

  • Radiological and Ultrasound Technology
  • Radiation
  • Radiology Nuclear Medicine and imaging
  • Public Health, Environmental and Occupational Health

Cite this

Microdosimetric study for interpretation of outcomes from boron neutron capture therapy clinical trials. / Nichols, T. L.; Miller, L. F.; Kabalka, George; Dudney, Tina.

In: Radiation Protection Dosimetry, Vol. 126, No. 1-4, 01.12.2007, p. 645-647.

Research output: Contribution to journalArticle

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