Microfluidics integrated biosensors

A leading technology towards lab-on-A-chip and sensing applications

George Luka, Ali Ahmadi, Homayoun Najjaran, Evangelyn Alocilja, Maria Derosa, Kirsten Wolthers, Ahmed Malki, Hassan Abdel-Aziz, Asmaa Althani, Mina Hoorfar

Research output: Contribution to journalReview article

84 Citations (Scopus)

Abstract

A biosensor can be defined as a compact analytical device or unit incorporating a biological or biologically derived sensitive recognition element immobilized on a physicochemical transducer to measure one or more analytes. Microfluidic systems, on the other hand, provide throughput processing, enhance transport for controlling the flow conditions, increase the mixing rate of different reagents, reduce sample and reagents volume (down to nanoliter), increase sensitivity of detection, and utilize the same platform for both sample preparation and detection. In view of these advantages, the integration of microfluidic and biosensor technologies provides the ability to merge chemical and biological components into a single platform and offers new opportunities for future biosensing applications including portability, disposability, real-time detection, unprecedented accuracies, and simultaneous analysis of different analytes in a single device. This review aims at representing advances and achievements in the field of microfluidic-based biosensing. The review also presents examples extracted from the literature to demonstrate the advantages of merging microfluidic and biosensing technologies and illustrate the versatility that such integration promises in the future biosensing for emerging areas of biological engineering, biomedical studies, point-of-care diagnostics, environmental monitoring, and precision agriculture.

Original languageEnglish (US)
Pages (from-to)30011-30031
Number of pages21
JournalSensors (Switzerland)
Volume15
Issue number12
DOIs
StatePublished - Dec 1 2015

Fingerprint

Microfluidics
Biosensing Techniques
bioinstrumentation
Biosensors
chips
Technology
reagents
platforms
Disposability
environmental monitoring
agriculture
Point-of-Care Systems
versatility
Bioengineering
Equipment and Supplies
Aptitude
Environmental Monitoring
emerging
transducers
Agriculture

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Atomic and Molecular Physics, and Optics
  • Biochemistry
  • Instrumentation
  • Electrical and Electronic Engineering

Cite this

Luka, G., Ahmadi, A., Najjaran, H., Alocilja, E., Derosa, M., Wolthers, K., ... Hoorfar, M. (2015). Microfluidics integrated biosensors: A leading technology towards lab-on-A-chip and sensing applications. Sensors (Switzerland), 15(12), 30011-30031. https://doi.org/10.3390/s151229783

Microfluidics integrated biosensors : A leading technology towards lab-on-A-chip and sensing applications. / Luka, George; Ahmadi, Ali; Najjaran, Homayoun; Alocilja, Evangelyn; Derosa, Maria; Wolthers, Kirsten; Malki, Ahmed; Abdel-Aziz, Hassan; Althani, Asmaa; Hoorfar, Mina.

In: Sensors (Switzerland), Vol. 15, No. 12, 01.12.2015, p. 30011-30031.

Research output: Contribution to journalReview article

Luka, G, Ahmadi, A, Najjaran, H, Alocilja, E, Derosa, M, Wolthers, K, Malki, A, Abdel-Aziz, H, Althani, A & Hoorfar, M 2015, 'Microfluidics integrated biosensors: A leading technology towards lab-on-A-chip and sensing applications', Sensors (Switzerland), vol. 15, no. 12, pp. 30011-30031. https://doi.org/10.3390/s151229783
Luka, George ; Ahmadi, Ali ; Najjaran, Homayoun ; Alocilja, Evangelyn ; Derosa, Maria ; Wolthers, Kirsten ; Malki, Ahmed ; Abdel-Aziz, Hassan ; Althani, Asmaa ; Hoorfar, Mina. / Microfluidics integrated biosensors : A leading technology towards lab-on-A-chip and sensing applications. In: Sensors (Switzerland). 2015 ; Vol. 15, No. 12. pp. 30011-30031.
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