Microinjection of neostigmine into the pontine reticular formation of cats enhances desynchronized sleep signs

Helen Baghdoyan, A. P. Monaco, M. L. Rodrigo-Angulo

Research output: Contribution to journalArticle

114 Citations (Scopus)

Abstract

Microinjection of the acetylcholinesterase inhibitor neostigmine into the dorsal pontine tegmentum of intact, freely moving cats produced significant changes in electrographic desynchronized (D) sleep signs and D sleep-like behavior. The percentage, frequency and duration of D sleep signs were increased and the latency to onset of D sleep signs was significantly reduced after neostigmine administration. The effects of neostigmine were dose-dependent and could be blocked by centrally administered atropine. This is the first demonstration that microinjection of an acetylcholinesterase inhibitor into the pons enhances D sleep signs. These data suggest that endogenously released acetylcholine can initiate and maintain the state of D sleep and strongly support the cholinergic hypothesis of D sleep generation.

Original languageEnglish (US)
Pages (from-to)173-180
Number of pages8
JournalJournal of Pharmacology and Experimental Therapeutics
Volume231
Issue number1
StatePublished - Jan 1 1984
Externally publishedYes

Fingerprint

Neostigmine
Microinjections
Sleep
Cats
Cholinesterase Inhibitors
Pons
Pontine Tegmentum
Atropine
Cholinergic Agents
Acetylcholine

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

Cite this

Microinjection of neostigmine into the pontine reticular formation of cats enhances desynchronized sleep signs. / Baghdoyan, Helen; Monaco, A. P.; Rodrigo-Angulo, M. L.

In: Journal of Pharmacology and Experimental Therapeutics, Vol. 231, No. 1, 01.01.1984, p. 173-180.

Research output: Contribution to journalArticle

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