Microphthalmia transcription factor and NKI/C3 expression in cellular neurothekeoma

Robert Page, Roy King, Martin C. Mihm, Paul Googe

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

While the usual or myxoid-type neurothekeoma has been reasonably well established as being a tumor of neural origin, the cellular neurothekeoma remains in disputed histogenesis. We studied a series of 11 cellular neurothekeomas using paraffin immunoperoxidase staining with microphthalmia transcription factor (Mitf), NKI/C3, and S-100. The majority of the tumors in our series stained with NKI/C3 (9/11) and Mitf (9/11). All failed to stain with S-100. Furthermore, we divided our series of cellular neurothekeomas according to cytomorphology; tumors demonstrating predominantly spindled morphology, predominantly epithelioid morphology, and mixed spindle and epithelioid morphology. The two tumors that failed to stain with NKI/C3 both demonstrated predominantly spindled morphology. One of the tumors that failed to stain with Mitf showed exclusive spindled morphology, while the other showed mixed morphology (spindle and epithelioid). Two of the tumors, which stained strongly with Mitf, however, showed exclusive epithelioid morphology. This current study furthers the concept that cellular neurothekeoma is a tumor of neuroectodermal origin, and further suggests that it may express some component of melanocytic differentiation.

Original languageEnglish (US)
Pages (from-to)230-234
Number of pages5
JournalModern Pathology
Volume17
Issue number2
DOIs
StatePublished - Feb 1 2004

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Neurothekeoma
Microphthalmia-Associated Transcription Factor
Neoplasms
Coloring Agents
Neuroectodermal Tumors
Paraffin
Staining and Labeling

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Microphthalmia transcription factor and NKI/C3 expression in cellular neurothekeoma. / Page, Robert; King, Roy; Mihm, Martin C.; Googe, Paul.

In: Modern Pathology, Vol. 17, No. 2, 01.02.2004, p. 230-234.

Research output: Contribution to journalArticle

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