MicroRNA-22 promotes cell survival upon UV radiation by repressing PTEN

Guangyun Tan, Yuling Shi, Zhaohui Wu

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

DNA damage response upon UV radiation involves a complex network of cellular events required for maintaining the homeostasis and restoring genomic stability of the cells. As a new class of players involved in DNA damage response, the regulation and function of microRNAs in response to UV remain poorly understood. Here we show that UV radiation induces a significant increase of miR-22 expression, which appears to be dependent on the activation of DNA damage responding kinase ATM (ataxia telangiectasia mutated). Increased miR-22 expression may result from enhanced miR-22 maturation in cells exposed to UV. We further found that tumor suppressor gene phosphatase and tensin homolog (PTEN) expression was inversely correlated with miR-22 induction and UV-induced PTEN repression was attenuated by overexpression of a miR-22 inhibitor. Moreover, increased miR-22 expression significantly inhibited the activation of caspase signaling cascade, leading to enhanced cell survival upon UV radiation. Collectively, these results indicate that miR-22 is an important player in the cellular stress response upon UV radiation, which may promote cell survival via the repression of PTEN expression.

Original languageEnglish (US)
Pages (from-to)546-551
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume417
Issue number1
DOIs
StatePublished - Jan 6 2012

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MicroRNAs
Phosphoric Monoester Hydrolases
Ultraviolet radiation
Cell Survival
Cells
Radiation
DNA Damage
DNA
Chemical activation
Ataxia Telangiectasia
Genomic Instability
Complex networks
Caspases
Tumor Suppressor Genes
Tumors
Homeostasis
Phosphotransferases
Genes
Tensins

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

MicroRNA-22 promotes cell survival upon UV radiation by repressing PTEN. / Tan, Guangyun; Shi, Yuling; Wu, Zhaohui.

In: Biochemical and Biophysical Research Communications, Vol. 417, No. 1, 06.01.2012, p. 546-551.

Research output: Contribution to journalArticle

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