MicroRNA-361

A multifaceted player regulating tumor aggressiveness and tumor microenvironment formation

Daozhi Xu, Peixin Dong, Ying Xiong, Junming Yue, Kei Ihira, Yosuke Konno, Noriko Kobayashi, Yukiharu Todo, Hidemichi Watari

Research output: Contribution to journalArticle

Abstract

MicroRNA-361-5p (miR-361) expression frequently decreases or is lost in different types of cancers, and contributes to tumor suppression by repressing the expression of its target genes implicated in tumor growth, epithelial-to-mesenchymal transition (EMT), metastasis, drug resistance, glycolysis, angiogenesis, and inflammation. Here, we review the expression pattern of miR-361 in human tumors, describe the mechanisms responsible for its dysregulation, and discuss how miR-361 modulates the aggressive properties of tumor cells and alter the tumor microenvironment by acting as a novel tumor suppressor. Furthermore, we describe its potentials as a promising diagnostic or prognostic biomarker for cancers and a promising target for therapeutic development.

Original languageEnglish (US)
Article number1130
JournalCancers
Volume11
Issue number8
DOIs
StatePublished - Aug 1 2019

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Tumor Microenvironment
MicroRNAs
Neoplasms
Epithelial-Mesenchymal Transition
Glycolysis
Tumor Biomarkers
Switzerland
Drug Resistance
Neoplasm Metastasis
Inflammation
Growth
Genes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

MicroRNA-361 : A multifaceted player regulating tumor aggressiveness and tumor microenvironment formation. / Xu, Daozhi; Dong, Peixin; Xiong, Ying; Yue, Junming; Ihira, Kei; Konno, Yosuke; Kobayashi, Noriko; Todo, Yukiharu; Watari, Hidemichi.

In: Cancers, Vol. 11, No. 8, 1130, 01.08.2019.

Research output: Contribution to journalArticle

Xu, D, Dong, P, Xiong, Y, Yue, J, Ihira, K, Konno, Y, Kobayashi, N, Todo, Y & Watari, H 2019, 'MicroRNA-361: A multifaceted player regulating tumor aggressiveness and tumor microenvironment formation', Cancers, vol. 11, no. 8, 1130. https://doi.org/10.3390/cancers11081130
Xu, Daozhi ; Dong, Peixin ; Xiong, Ying ; Yue, Junming ; Ihira, Kei ; Konno, Yosuke ; Kobayashi, Noriko ; Todo, Yukiharu ; Watari, Hidemichi. / MicroRNA-361 : A multifaceted player regulating tumor aggressiveness and tumor microenvironment formation. In: Cancers. 2019 ; Vol. 11, No. 8.
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