MicroRNA trafficking and human cancer

Research output: Contribution to journalReview article

27 Citations (Scopus)

Abstract

MicroRNAs (miRNAs) are short endogenous noncoding small RNA molecules with 21 to 25 nucleotides (nt) in length, which negatively regulate gene expression either by degrading specific mRNA or impeding translation at the transcriptional and post-transcriptional level. Recent advances suggest that miRNAs play prominent roles in development, genome organization, viral and transposon defense, and human disease, including neurodegenerative and metabolic diseases. Surprisingly, miRNAs are now linked with a variety of cancers, in which a reduced expression or overexpression may lead to oncogene or tumor suppressor gene-like actions. Here we will overview the miRNA pathway and its regulation with emphasis on the links with human cancer. Finally potential applications of miRNA in tumor diagnosis and therapy will be discussed.

Original languageEnglish (US)
Pages (from-to)573-578
Number of pages6
JournalCancer Biology and Therapy
Volume5
Issue number6
DOIs
StatePublished - Jan 1 2006

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Human Trafficking
MicroRNAs
Neoplasms
Small Untranslated RNA
Viral Genome
Metabolic Diseases
Tumor Suppressor Genes
Oncogenes
Neurodegenerative Diseases
Nucleotides
Gene Expression
Messenger RNA

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Oncology
  • Pharmacology
  • Cancer Research

Cite this

MicroRNA trafficking and human cancer. / Yue, Junming; Tigyi, Gabor.

In: Cancer Biology and Therapy, Vol. 5, No. 6, 01.01.2006, p. 573-578.

Research output: Contribution to journalReview article

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