Microtubule gelation-contraction

essential components and relation to slow axonal transport

Richard C. Weisenberg, James Flynn, Baochong Gao, Shuaibu Awodi, Frank Skee, Steven Goodman, Beat M. Riederer

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Preparations of microtubule proteins isolated by assembly and disassembly undergo gelation-contraction after addition of adenosine triphosphate (ATP). A particulate fraction from these preparations that is required, along with purified tubulin, to produce ATP-dependent microtubule gelation-contraction in vitro has been isolated. The particulates exhibited microtubule-stimulated adenosine triphosphatase activity and moved slowly (about 1 micrometer per minute) along microtubule walls in the presence of ATP. The particulates contained tubulin, neurofilament, and spectrin polypeptides. The composition, solubility, and motility of the particulates are consistent with those of slow component a of axonal transport.

Original languageEnglish (US)
Pages (from-to)1119-1122
Number of pages4
JournalScience
Volume238
Issue number4830
DOIs
StatePublished - Jan 1 1987
Externally publishedYes

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Axonal Transport
Microtubules
Adenosine Triphosphate
Tubulin
Microtubule Proteins
Spectrin
Intermediate Filaments
Solubility
Adenosine Triphosphatases
Peptides

All Science Journal Classification (ASJC) codes

  • General

Cite this

Weisenberg, R. C., Flynn, J., Gao, B., Awodi, S., Skee, F., Goodman, S., & Riederer, B. M. (1987). Microtubule gelation-contraction: essential components and relation to slow axonal transport. Science, 238(4830), 1119-1122. https://doi.org/10.1126/science.2446388

Microtubule gelation-contraction : essential components and relation to slow axonal transport. / Weisenberg, Richard C.; Flynn, James; Gao, Baochong; Awodi, Shuaibu; Skee, Frank; Goodman, Steven; Riederer, Beat M.

In: Science, Vol. 238, No. 4830, 01.01.1987, p. 1119-1122.

Research output: Contribution to journalArticle

Weisenberg, RC, Flynn, J, Gao, B, Awodi, S, Skee, F, Goodman, S & Riederer, BM 1987, 'Microtubule gelation-contraction: essential components and relation to slow axonal transport', Science, vol. 238, no. 4830, pp. 1119-1122. https://doi.org/10.1126/science.2446388
Weisenberg, Richard C. ; Flynn, James ; Gao, Baochong ; Awodi, Shuaibu ; Skee, Frank ; Goodman, Steven ; Riederer, Beat M. / Microtubule gelation-contraction : essential components and relation to slow axonal transport. In: Science. 1987 ; Vol. 238, No. 4830. pp. 1119-1122.
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