MiRNA and vascular cell movement

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

miRNAs are a new class of endogenous small RNAs that negatively regulate gene expression at the posttranscriptional level. Accumulating experimental evidence shows that miRNAs regulate cellular apoptosis, proliferation, differentiation, and migration. Dysregulation of miRNA expression leads to various human diseases including cancer and cardiovascular disease. miRNA maturation is regulated at multiple steps by different mechanisms, including miRNA editing, hairpin loop binding, self-regulation, and cross-talk with other signaling pathways. Vascular cell movement plays a pivotal role in the development of various cancers and cardiovascular diseases. miRNAs have been found to regulate vascular cell movement. Presently the chemically synthesized antagomir and miRNA mimics have been widely used in investigating the biological functions of miRNA genes. The viral vectors, including adenoviral, lentiviral, and adeno-associated viral vectors, have been used to efficiently overexpress or knockdown miRNAs in vitro and in vivo. Therefore, targeting vascular cell movement using miRNA-based drug or gene therapy would provide a novel therapeutic approach in the treatment of cancers and vascular diseases.

Original languageEnglish (US)
Pages (from-to)616-622
Number of pages7
JournalAdvanced Drug Delivery Reviews
Volume63
Issue number8
DOIs
StatePublished - Jul 18 2011

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MicroRNAs
Cell Movement
Blood Vessels
Cardiovascular Diseases
Neoplasms
Vascular Diseases
Genetic Therapy
Cell Proliferation
RNA
Apoptosis
Gene Expression
Drug Therapy
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Cite this

MiRNA and vascular cell movement. / Yue, Junming.

In: Advanced Drug Delivery Reviews, Vol. 63, No. 8, 18.07.2011, p. 616-622.

Research output: Contribution to journalReview article

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