MiRNAs in kidney transplantation

Potential role as new biomarkers

Mariano J. Scian, Daniel Maluf, Valeria Mas

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

MiRNAs (miRNAs) are a class of small endogenous, noncoding RNAs with important roles in regulating gene expression known to play a role in many cellular functions including cellular differentiation, cell proliferation, cell development and functional regulation of the immune system, among others. As such, miRNAs are emerging not only as potential biomarkers but also as potential therapeutic targets. Here, we review the currently published work on miRNAs and renal transplantation as it pertains to ischemia-reperfusion injury, acute kidney injury, delayed graft function, calcineurin inhibitor toxicity, acute rejection, chronic allograft dysfunction and kidney fibrosis.

Original languageEnglish (US)
Pages (from-to)93-104
Number of pages12
JournalExpert Review of Molecular Diagnostics
Volume13
Issue number1
DOIs
StatePublished - Jan 1 2013
Externally publishedYes

Fingerprint

MicroRNAs
Kidney Transplantation
Biomarkers
Delayed Graft Function
Small Untranslated RNA
Reperfusion Injury
Acute Kidney Injury
Allografts
Immune System
Fibrosis
Cell Proliferation
Kidney
Gene Expression
Therapeutics

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Pathology and Forensic Medicine

Cite this

MiRNAs in kidney transplantation : Potential role as new biomarkers. / Scian, Mariano J.; Maluf, Daniel; Mas, Valeria.

In: Expert Review of Molecular Diagnostics, Vol. 13, No. 1, 01.01.2013, p. 93-104.

Research output: Contribution to journalReview article

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