Mitochondria initiate and regulate sarcopenia

Stephen Alway, Junaith Mohamed, Matthew J. Myers

Research output: Contribution to journalReview article

16 Citations (Scopus)

Abstract

We present the hypothesis that an accumulation of dysfunctional mitochondria initiates a signaling cascade leading to motor neuron and muscle fiber death and culminating in sarcopenia. Interactions between neural and muscle cells that contain dysfunctional mitochondria exacerbate sarcopenia. Preventing sarcopenia will require identifying mitochondrial sources of dysfunction that are reversible.

Original languageEnglish (US)
Pages (from-to)58-69
Number of pages12
JournalExercise and sport sciences reviews
Volume45
Issue number2
DOIs
StatePublished - Jan 1 2017

Fingerprint

Sarcopenia
Mitochondria
Motor Neurons
Muscle Cells
Muscles

All Science Journal Classification (ASJC) codes

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Mitochondria initiate and regulate sarcopenia. / Alway, Stephen; Mohamed, Junaith; Myers, Matthew J.

In: Exercise and sport sciences reviews, Vol. 45, No. 2, 01.01.2017, p. 58-69.

Research output: Contribution to journalReview article

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