Mitochondrial dysfunction, endoplasmic reticulum stress, and apoptosis in Alzheimer's disease

Kazuhiro Takuma, Shirley Shi Du Yan, David Stern, Kiyofumi Yamada

Research output: Contribution to journalReview article

91 Citations (Scopus)

Abstract

Alzheimer's disease (AD) is the most common neurodegenerative disorder of late life characterized by insidious, chronic, and progressive memory impairment in association with the accumulation of senile plaques, neurofibrillary tangles, and massive loss of neurons. Apoptosis is believed to be an important contributor to progression and pathology of neurodegeneration in AD. There is considerable evidence that amyloid β-peptide, a major component of senile plaques, has the capacity to activate intracellular apoptosis pathways leading to neuronal cell death. AD-related mutations in genes coding presenilins are also shown to cause neuronal apoptosis, by directly and indirectly regulating apoptotic signaling cascades. Recent evidence suggests that two intrinsic pathways, mitochondrial dysfunction and endoplasmic reticulum stress, are central in the execution of apoptosis in AD. This review summarizes recent progress of research in this field focused on the molecular mechanisms involved in neuronal apoptosis mediated by organelle dysfunction.

Original languageEnglish (US)
Pages (from-to)312-316
Number of pages5
JournalJournal of Pharmacological Sciences
Volume97
Issue number3
DOIs
StatePublished - Mar 1 2005

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Endoplasmic Reticulum Stress
Alzheimer Disease
Apoptosis
Amyloid Plaques
Presenilins
Neurofibrillary Tangles
Amyloid
Neurodegenerative Diseases
Organelles
Cell Death
Pathology
Neurons
Peptides
Mutation
Research
Genes

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

Cite this

Mitochondrial dysfunction, endoplasmic reticulum stress, and apoptosis in Alzheimer's disease. / Takuma, Kazuhiro; Yan, Shirley Shi Du; Stern, David; Yamada, Kiyofumi.

In: Journal of Pharmacological Sciences, Vol. 97, No. 3, 01.03.2005, p. 312-316.

Research output: Contribution to journalReview article

Takuma, Kazuhiro ; Yan, Shirley Shi Du ; Stern, David ; Yamada, Kiyofumi. / Mitochondrial dysfunction, endoplasmic reticulum stress, and apoptosis in Alzheimer's disease. In: Journal of Pharmacological Sciences. 2005 ; Vol. 97, No. 3. pp. 312-316.
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