Mitochondrial Encephalomyopathy with Lactic Acidosis and Strokelike Episodes (MELAS)

A Mitochondrial Disorder Presents as Fibromyalgia

Rowena A. DeSouza, Raul J. Cardenas, Tekisha U. Lindler, Francisco A. De La Fuente, Francisco J. Mayorquin, David S. Trochtenberg

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

This case report describes a patient who presented with symptoms and signs of longstanding fibromyalgia. Routine laboratory tests revealed an elevated anion gap. Evaluation of the elevated anion gap demonstrated elevated lactate and pyruvate levels and a lactate-to-pyruvate ratio greater than 20:1. A muscle biopsy was performed, exhibiting red ragged fibers, pathognomonic for a mitochondrial disorder. The patient was diagnosed with mitochondrial encephalomyopathy with lactic acidosis and strokelike episodes (MELAS). This is the first report describing fibromyalgia as the initial presentation of MELAS. This article outlines the diagnostic process that can assist the physician in distinguishing mitochondrial disorders from other muscular diseases, particularly fibromyalgia.

Original languageEnglish (US)
Pages (from-to)528-531
Number of pages4
JournalSouthern Medical Journal
Volume97
Issue number5
DOIs
StatePublished - May 2004
Externally publishedYes

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Mitochondrial Encephalomyopathies
Mitochondrial Diseases
Lactic Acidosis
Fibromyalgia
Acid-Base Equilibrium
Pyruvic Acid
Lactic Acid
Muscular Diseases
Signs and Symptoms
Physicians
Biopsy
Muscles

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

DeSouza, R. A., Cardenas, R. J., Lindler, T. U., De La Fuente, F. A., Mayorquin, F. J., & Trochtenberg, D. S. (2004). Mitochondrial Encephalomyopathy with Lactic Acidosis and Strokelike Episodes (MELAS): A Mitochondrial Disorder Presents as Fibromyalgia. Southern Medical Journal, 97(5), 528-531. https://doi.org/10.1097/00007611-200405000-00023

Mitochondrial Encephalomyopathy with Lactic Acidosis and Strokelike Episodes (MELAS) : A Mitochondrial Disorder Presents as Fibromyalgia. / DeSouza, Rowena A.; Cardenas, Raul J.; Lindler, Tekisha U.; De La Fuente, Francisco A.; Mayorquin, Francisco J.; Trochtenberg, David S.

In: Southern Medical Journal, Vol. 97, No. 5, 05.2004, p. 528-531.

Research output: Contribution to journalArticle

DeSouza, Rowena A. ; Cardenas, Raul J. ; Lindler, Tekisha U. ; De La Fuente, Francisco A. ; Mayorquin, Francisco J. ; Trochtenberg, David S. / Mitochondrial Encephalomyopathy with Lactic Acidosis and Strokelike Episodes (MELAS) : A Mitochondrial Disorder Presents as Fibromyalgia. In: Southern Medical Journal. 2004 ; Vol. 97, No. 5. pp. 528-531.
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