Mitogenic signal transduction pathways in meningiomas: Novel targets for meningioma chemotherapy?

Mahlon Johnson, Steven Toms

Research output: Contribution to journalReview article

40 Citations (Scopus)

Abstract

The roles of growth factor receptors and numerous downstream growth regulatory pathways are of increasing interest in neurooncology. These pathways have been extensively studied in gliomas but only recently analyzed in meningiomas. This article reviews current research on the growth factor receptor-Ras-Raf-1-MEK-1-MAPK, PI3K-Akt/PKB, PLC-γ1-PKC, phospholipase A2-cyclooxygenase, and TGF-β receptor-Smad pathways that appear to regulate meningioma growth and inhibit apoptosis. Sites along these receptor/kinase cascades that might be targeted by novel therapies are also discussed.

Original languageEnglish (US)
Pages (from-to)1029-1036
Number of pages8
JournalJournal of Neuropathology and Experimental Neurology
Volume64
Issue number12
DOIs
StatePublished - Dec 1 2005
Externally publishedYes

Fingerprint

Growth Factor Receptors
Meningioma
Signal Transduction
Drug Therapy
Phospholipases A2
Mitogen-Activated Protein Kinase Kinases
Prostaglandin-Endoperoxide Synthases
Growth
Phosphatidylinositol 3-Kinases
Glioma
Phosphotransferases
Apoptosis
Research
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Cite this

Mitogenic signal transduction pathways in meningiomas : Novel targets for meningioma chemotherapy? / Johnson, Mahlon; Toms, Steven.

In: Journal of Neuropathology and Experimental Neurology, Vol. 64, No. 12, 01.12.2005, p. 1029-1036.

Research output: Contribution to journalReview article

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