Mitral Valve Prolapse in Women With Oral Contraceptive-Related Cerebrovascular Insufficiency

Associated Persistent Hypercoagulable State

Marshall Elam, Mary J. Viar, Thomas E. Ratts, Carolyn M. Chesney

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

We examined a group of former oral contraceptive (OC) users, who had experienced cerebrovascular insufficiency, for the presence of hypercoagulable states. We found hypercoagulability in this group in the form of decreased plasma anti-thrombin III activity, increased platelet coagulant activity, and elevated plasma β-thromboglobulin level. Certain characteristics (cigarette smoking, vascular headache, hyperlipidemia, and mitral valve prolapse) were encountered with increased frequency among former OC users who had experienced cerebrovascular insufficiency. The association of mitral valve prolapse with OC-related cerebrovascular insufficiency was particularly striking. We propose that preexisting hypercoagulable states, such as may exist in a subset of individuals with mitral valve prolapse, will magnify the risk of OC-related cerebrovascular morbidity.

Original languageEnglish (US)
Pages (from-to)73-77
Number of pages5
JournalArchives of Internal Medicine
Volume146
Issue number1
DOIs
StatePublished - Jan 1 1986
Externally publishedYes

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Cerebrovascular Disorders
Mitral Valve Prolapse
Oral Contraceptives
Vascular Headaches
Coagulants
Thrombophilia
Hyperlipidemias
Thrombin
Blood Platelets
Smoking
Morbidity

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Mitral Valve Prolapse in Women With Oral Contraceptive-Related Cerebrovascular Insufficiency : Associated Persistent Hypercoagulable State. / Elam, Marshall; Viar, Mary J.; Ratts, Thomas E.; Chesney, Carolyn M.

In: Archives of Internal Medicine, Vol. 146, No. 1, 01.01.1986, p. 73-77.

Research output: Contribution to journalArticle

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