Model of the dynamics of intracranial pressure during conditions of intact and loss of cerebral vascular tone

Eryu Wang, James T. Robertson, Charles Leffler, Michael L. Daley

Research output: Contribution to journalConference article

Abstract

A mathematical model has been developed to simulate the dynamics of intracranial pressure and cerebral blood flow. This model is based on the hypothesis that during the condition of normal vascular tone a major component of venous blood flow into the superior sagittal sinus is reduced during positive pressure inhalation. In contrast, during loss of vascular tone and massive vasodilation, venous blood flow is not markedly reduced during positive pressure inhalation. A non-linear resistance was used to simulate the pressure dependent behavior of both the resistance of bridging veins into the lateral lacuna and resistance of elements of chordae Willisii along the walls of the sagittal sinus. All parameters of the model were obtained from previously published values or direct calculation using the available physiologic data and analog simulation. A comparison between the experimentally recorded and simulated intracranial pressure signals demonstrates the possible validity of the model.

Original languageEnglish (US)
Pages (from-to)1515-1516
Number of pages2
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume17
Issue number2
StatePublished - Dec 1 1995
EventProceedings of the 1995 IEEE Engineering in Medicine and Biology 17th Annual Conference and 21st Canadian Medical and Biological Engineering Conference. Part 2 (of 2) - Montreal, Can
Duration: Sep 20 1995Sep 23 1995

Fingerprint

Intracranial Pressure
Blood Vessels
Pressure
Inhalation
Cerebrovascular Circulation
Blood
Superior Sagittal Sinus
Vasodilation
Veins
Theoretical Models
Mathematical models

All Science Journal Classification (ASJC) codes

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Cite this

Model of the dynamics of intracranial pressure during conditions of intact and loss of cerebral vascular tone. / Wang, Eryu; Robertson, James T.; Leffler, Charles; Daley, Michael L.

In: Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, Vol. 17, No. 2, 01.12.1995, p. 1515-1516.

Research output: Contribution to journalConference article

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