Modeling Disorders of Movement

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Human movement disorders can be modeled in flies, worms, zebrafish, mice, rats, nonhuman primates, and a variety of other vertebrate and invertebrate systems. However, human movement disorders are best studied in humans. Moreover, bioinformatics and computational tools can obviate the use of animal model systems. In general, model systems will rarely emulate all of the clinical, systems, molecular, and cellular features of the corresponding human disease. On the other hand, animal models can be used to address critical questions regarding the network and cellular pathobiology of human movement disorders that cannot be tackled by alternative means. In addition, unbiased study of model systems can beget novel insights into sensorimotor networks and cell biology with impact beyond the domain of movement disorders.

Original languageEnglish (US)
Title of host publicationMovement Disorders
Subtitle of host publicationGenetics and Models: Second Edition
PublisherElsevier Inc.
Pages23-43
Number of pages21
ISBN (Print)9780124051959
DOIs
StatePublished - Jan 1 2015

Fingerprint

Movement Disorders
Animal Models
Zebrafish
Invertebrates
Computational Biology
Diptera
Primates
Cell Biology
Vertebrates

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Ledoux, M. (2015). Modeling Disorders of Movement. In Movement Disorders: Genetics and Models: Second Edition (pp. 23-43). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-405195-9.00002-0

Modeling Disorders of Movement. / Ledoux, Mark.

Movement Disorders: Genetics and Models: Second Edition. Elsevier Inc., 2015. p. 23-43.

Research output: Chapter in Book/Report/Conference proceedingChapter

Ledoux, M 2015, Modeling Disorders of Movement. in Movement Disorders: Genetics and Models: Second Edition. Elsevier Inc., pp. 23-43. https://doi.org/10.1016/B978-0-12-405195-9.00002-0
Ledoux M. Modeling Disorders of Movement. In Movement Disorders: Genetics and Models: Second Edition. Elsevier Inc. 2015. p. 23-43 https://doi.org/10.1016/B978-0-12-405195-9.00002-0
Ledoux, Mark. / Modeling Disorders of Movement. Movement Disorders: Genetics and Models: Second Edition. Elsevier Inc., 2015. pp. 23-43
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