Modification by choline of adrenergic transmission in rat mesenteric arteries

Kafait Malik, J. C. McGIFF

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The action of choline on the vasoconstrictor responses of the perfused mesenteric arteries of the rat to sympathetic nerve stimulation and to injected noradrenaline has been investigated. The infusion of choline (500 μg/ml), for periods of 15 s, increased the response to sympathetic nerve stimulation, whereas the infusion of the same concentration for 20 min greatly reduced the response to nerve stimulation. Choline (up to 500 μg/ml), infused either for short or long periods, did not alter the response to injected noradrenaline. The inhibitory action of choline on the response to nerve stimulation was abolished either by an increase in the calcium concentration from 1·8 to 5·4 mm or by simultaneous infusion of (+)‐amphetamine or atropine. The results suggest that choline in concentrations of 500 μg/ml has the same effect on adrenergic transmission in mesenteric arteries as acetylcholine at concentrations of 5 ng/ml. 1971 British Pharmacological Society

Original languageEnglish (US)
Pages (from-to)776-783
Number of pages8
JournalBritish Journal of Pharmacology
Volume43
Issue number4
DOIs
StatePublished - Jan 1 1971

Fingerprint

Mesenteric Arteries
Choline
Adrenergic Agents
Norepinephrine
Vasoconstrictor Agents
Amphetamine
Atropine
Acetylcholine
Calcium

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Modification by choline of adrenergic transmission in rat mesenteric arteries. / Malik, Kafait; McGIFF, J. C.

In: British Journal of Pharmacology, Vol. 43, No. 4, 01.01.1971, p. 776-783.

Research output: Contribution to journalArticle

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