Modulation by prostaglandins of adrenergic transmission in the isolated perfused rabbit and rat kidney

Kafait Malik, J. C. McGiff

Research output: Contribution to journalArticle

166 Citations (Scopus)

Abstract

In the isolated perfused rabbit kidney prostaglandins (PGs) E1 (0.02-0.1 ng/ml), E2 (0.02-0.1 ng/ml), and A2 (1-5 ng/ml) inhibited the vasoconstrictor responses to sympathetic nerve stimulation by 21-44%, 31-39%, and 20-23%, respectively, without altering those to injected norepinephrine. In contrast, in the rat kidney PGE1 (0.5 ng/ml), PGE2 (0.5 ng/ml), and PGA2 (5 ng/ml) enhanced the vasoconstrictor responses to sympathetic nerve stimulation by 41%, 27%, and 11%, respectively; the equiconstrictor responses to injected norepinephrine remained unaltered. Higher concentrations of these agents produced vasodilation in the rabbit kidney and vasoconstriction in the rat kidney. In both species PGF2(α) produced vasoconstriction and enhanced the responses to both adrenergic stimuli. In the rabbit kidney inhibitors of PG synthesis augmented the responses to sympathetic nerve stimulation without altering those to injected norepinephrine, whereas in the rat kidney inhibition of the responses to both adrenergic stimuli occurred. Arachidonic acid inhibited the vasoconstrictor responses to sympathetic nerve stimulation in the rabbit kidney, but in the rat kidney it caused augmentation of these responses. Since these effects of arachidonic acid were reduced by indomethacin, they appear to be mediated through the acid's conversion to PGs. It is concluded that PGs of the E series modulate adrenergic transmission in the kidney and that their modulatory actions are species dependent.

Original languageEnglish (US)
Pages (from-to)599-609
Number of pages11
JournalCirculation research
Volume36
Issue number5
DOIs
StatePublished - Jan 1 1975
Externally publishedYes

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Adrenergic Agents
Prostaglandins
Rabbits
Kidney
Vasoconstrictor Agents
Norepinephrine
Alprostadil
Vasoconstriction
Arachidonic Acid
Prostaglandin Antagonists
Dinoprost
Prostaglandins E
Dinoprostone
varespladib methyl
Vasodilation
Indomethacin
Acids

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Modulation by prostaglandins of adrenergic transmission in the isolated perfused rabbit and rat kidney. / Malik, Kafait; McGiff, J. C.

In: Circulation research, Vol. 36, No. 5, 01.01.1975, p. 599-609.

Research output: Contribution to journalArticle

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