Modulation of BK Channels by Ethanol

Alejandro Dopico, Anna Bukiya, G. Kuntamallappanavar, J. Liu

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Citations (Scopus)

Abstract

In alcohol-naïve systems, ethanol (< 100 mM) exposure of calcium-gated BK channels perturbs physiology and behavior. Brief (several minutes) ethanol exposure usually leads to increased BK current, which results from ethanol interaction with a pocket mapped to the BK channel-forming slo1 protein cytosolic tail domain. The importance of this region in ethanol-induced intoxication has been independently supported by an unbiased screen of Caenorhabditis elegans slo1 mutants. However, ethanol-induced BK activation is not universal as refractoriness and inhibition have been reported. The final effect depends on many factors, including intracellular calcium levels, slo1 isoform, BK beta subunit composition, posttranslational modification of BK proteins, channel lipid microenvironment, and type of ethanol administration. Studies in Drosophila melanogaster, C. elegans, and rodents show that protracted/repeated ethanol administration leads to tolerance to ethanol-induced modification of BK-driven physiology and behavior. Unveiling the mechanisms underlying tolerance is of major importance, as tolerance to ethanol has been proposed as predictor of risk for alcoholism.

Original languageEnglish (US)
Title of host publicationInternational Review of Neurobiology
PublisherAcademic Press Inc.
Pages239-279
Number of pages41
DOIs
StatePublished - Jan 1 2016

Publication series

NameInternational Review of Neurobiology
Volume128
ISSN (Print)0074-7742
ISSN (Electronic)2162-5514

Fingerprint

Large-Conductance Calcium-Activated Potassium Channels
Ethanol
Caenorhabditis elegans
Calcium
Post Translational Protein Processing
Drosophila melanogaster
Alcoholism
Tail
Rodentia
Protein Isoforms
Proteins
Alcohols
Lipids

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Cite this

Dopico, A., Bukiya, A., Kuntamallappanavar, G., & Liu, J. (2016). Modulation of BK Channels by Ethanol. In International Review of Neurobiology (pp. 239-279). (International Review of Neurobiology; Vol. 128). Academic Press Inc.. https://doi.org/10.1016/bs.irn.2016.03.019

Modulation of BK Channels by Ethanol. / Dopico, Alejandro; Bukiya, Anna; Kuntamallappanavar, G.; Liu, J.

International Review of Neurobiology. Academic Press Inc., 2016. p. 239-279 (International Review of Neurobiology; Vol. 128).

Research output: Chapter in Book/Report/Conference proceedingChapter

Dopico, A, Bukiya, A, Kuntamallappanavar, G & Liu, J 2016, Modulation of BK Channels by Ethanol. in International Review of Neurobiology. International Review of Neurobiology, vol. 128, Academic Press Inc., pp. 239-279. https://doi.org/10.1016/bs.irn.2016.03.019
Dopico A, Bukiya A, Kuntamallappanavar G, Liu J. Modulation of BK Channels by Ethanol. In International Review of Neurobiology. Academic Press Inc. 2016. p. 239-279. (International Review of Neurobiology). https://doi.org/10.1016/bs.irn.2016.03.019
Dopico, Alejandro ; Bukiya, Anna ; Kuntamallappanavar, G. ; Liu, J. / Modulation of BK Channels by Ethanol. International Review of Neurobiology. Academic Press Inc., 2016. pp. 239-279 (International Review of Neurobiology).
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