Modulation of HLA -DR in dry eye patients following 30 days of treatment with a lubricant eyedrop solution

Karen B. Fernandez, Seth P. Epstein, Geoffrey S. Raynor, Alan T. Sheyman, Morgan L. Massingale, Peter G. Dentone, Lukas D. Landegger, Penny Asbell

Research output: Contribution to journalArticle

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Abstract

Purpose: To determine the changes in dry eye disease (DED) severity and the percentage of cells expressing HLA-DR on the ocular surface following treatment with lubricant eyedrops containing polyethylene glycol and propylene glycol (PEG/PG) and the gelling agent hydroxypropyl guar (HP-Guar). Patients and methods: Nineteen patients with DED used PEG/PG + HP-Guar eyedrops four times per day for 30 days. Assessments included DED severity (Ocular Surface Disease Index [OSDI], corneal staining, conjunctival staining, tear film break-up time [TFBUT], and Schirmer testing) and impression cytology of the conjunctiva with masked flow cytometry at baseline and at 30 days. Results: There was a significant decrease in corneal staining (P<0.01), OSDI (P=0.02), and TFBUT (P<0.01) following treatment with PEG/PG + HP-Guar. Results from flow cytometry revealed a significant decrease in cells expressing HLA-DR (P=0.02). Conclusion: Treatment with PEG/PG + HP-Guar eyedrops showed improvement in dry eye severity and reduction in surface inflammation as indicated by a reduction in HLA-DR expression.

Original languageEnglish (US)
Pages (from-to)1137-1145
Number of pages9
JournalClinical Ophthalmology
Volume9
DOIs
StatePublished - Jun 24 2015

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Lubricants
Eye Diseases
Ophthalmic Solutions
HLA-DR Antigens
Propylene Glycol
Staining and Labeling
Tears
Flow Cytometry
Therapeutics
Conjunctiva
Cell Biology
Inflammation
hydroxypropyl guar

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Cite this

Fernandez, K. B., Epstein, S. P., Raynor, G. S., Sheyman, A. T., Massingale, M. L., Dentone, P. G., ... Asbell, P. (2015). Modulation of HLA -DR in dry eye patients following 30 days of treatment with a lubricant eyedrop solution. Clinical Ophthalmology, 9, 1137-1145. https://doi.org/10.2147/OPTH.S81355

Modulation of HLA -DR in dry eye patients following 30 days of treatment with a lubricant eyedrop solution. / Fernandez, Karen B.; Epstein, Seth P.; Raynor, Geoffrey S.; Sheyman, Alan T.; Massingale, Morgan L.; Dentone, Peter G.; Landegger, Lukas D.; Asbell, Penny.

In: Clinical Ophthalmology, Vol. 9, 24.06.2015, p. 1137-1145.

Research output: Contribution to journalArticle

Fernandez, KB, Epstein, SP, Raynor, GS, Sheyman, AT, Massingale, ML, Dentone, PG, Landegger, LD & Asbell, P 2015, 'Modulation of HLA -DR in dry eye patients following 30 days of treatment with a lubricant eyedrop solution', Clinical Ophthalmology, vol. 9, pp. 1137-1145. https://doi.org/10.2147/OPTH.S81355
Fernandez KB, Epstein SP, Raynor GS, Sheyman AT, Massingale ML, Dentone PG et al. Modulation of HLA -DR in dry eye patients following 30 days of treatment with a lubricant eyedrop solution. Clinical Ophthalmology. 2015 Jun 24;9:1137-1145. https://doi.org/10.2147/OPTH.S81355
Fernandez, Karen B. ; Epstein, Seth P. ; Raynor, Geoffrey S. ; Sheyman, Alan T. ; Massingale, Morgan L. ; Dentone, Peter G. ; Landegger, Lukas D. ; Asbell, Penny. / Modulation of HLA -DR in dry eye patients following 30 days of treatment with a lubricant eyedrop solution. In: Clinical Ophthalmology. 2015 ; Vol. 9. pp. 1137-1145.
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