Molecular and cellular events at the site of myocardial infarction

From the perspective of rebuilding myocardial tissue

Li Lu, John Q. Zhang, Felix J. Ramires, Yao Sun

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

The potential for bone marrow-derived progenitor cells (BMDPC) to regenerate myocardial tissue following infarction depends on homing, migration, nourishment, and spatially appropriate growth of BMDPC. Requisite to these objectives is the expression of adhesion molecules (ICAM-1) and chemoattractant cytokines (MCP-1), matrix metalloproteinase (MMP) activity, a neovasculature, and fibrillar collagen scaffolding. We found that enhanced ICAM-l and MCP-1, as well as MMP activity on day 3 and 7 postMI, are present to facilitate the homing, chemotaxis, and migration of circulating cells into the infarct site. The vascular network formed at the infarct site contains a ratio of conduit to exchange vessels that is greater than that for control tissue and therefore its ability to nourish BMDPC for their growth appears to be tenuous. These findings, together with the dense formation of a fibrillar collagen scar beyond week 2, suggest the optimal time to rebuild myocardium from BMDPC resides within 2 week postMI.

Original languageEnglish (US)
Pages (from-to)907-913
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume320
Issue number3
DOIs
StatePublished - Jul 30 2004

Fingerprint

Bone
Stem Cells
Bone Marrow
Myocardial Infarction
Fibrillar Collagens
Tissue
Matrix Metalloproteinase 1
Aptitude
Chemotactic Factors
Chemotaxis
Intercellular Adhesion Molecule-1
Growth
Matrix Metalloproteinases
Infarction
Cell Movement
Cicatrix
Blood Vessels
Myocardium
Adhesion
Cells

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Molecular and cellular events at the site of myocardial infarction : From the perspective of rebuilding myocardial tissue. / Lu, Li; Zhang, John Q.; Ramires, Felix J.; Sun, Yao.

In: Biochemical and Biophysical Research Communications, Vol. 320, No. 3, 30.07.2004, p. 907-913.

Research output: Contribution to journalArticle

@article{0c1dde5e54bb41cab32ef13cf248e1ae,
title = "Molecular and cellular events at the site of myocardial infarction: From the perspective of rebuilding myocardial tissue",
abstract = "The potential for bone marrow-derived progenitor cells (BMDPC) to regenerate myocardial tissue following infarction depends on homing, migration, nourishment, and spatially appropriate growth of BMDPC. Requisite to these objectives is the expression of adhesion molecules (ICAM-1) and chemoattractant cytokines (MCP-1), matrix metalloproteinase (MMP) activity, a neovasculature, and fibrillar collagen scaffolding. We found that enhanced ICAM-l and MCP-1, as well as MMP activity on day 3 and 7 postMI, are present to facilitate the homing, chemotaxis, and migration of circulating cells into the infarct site. The vascular network formed at the infarct site contains a ratio of conduit to exchange vessels that is greater than that for control tissue and therefore its ability to nourish BMDPC for their growth appears to be tenuous. These findings, together with the dense formation of a fibrillar collagen scar beyond week 2, suggest the optimal time to rebuild myocardium from BMDPC resides within 2 week postMI.",
author = "Li Lu and Zhang, {John Q.} and Ramires, {Felix J.} and Yao Sun",
year = "2004",
month = "7",
day = "30",
doi = "10.1016/j.bbrc.2004.06.034",
language = "English (US)",
volume = "320",
pages = "907--913",
journal = "Biochemical and Biophysical Research Communications",
issn = "0006-291X",
publisher = "Academic Press Inc.",
number = "3",

}

TY - JOUR

T1 - Molecular and cellular events at the site of myocardial infarction

T2 - From the perspective of rebuilding myocardial tissue

AU - Lu, Li

AU - Zhang, John Q.

AU - Ramires, Felix J.

AU - Sun, Yao

PY - 2004/7/30

Y1 - 2004/7/30

N2 - The potential for bone marrow-derived progenitor cells (BMDPC) to regenerate myocardial tissue following infarction depends on homing, migration, nourishment, and spatially appropriate growth of BMDPC. Requisite to these objectives is the expression of adhesion molecules (ICAM-1) and chemoattractant cytokines (MCP-1), matrix metalloproteinase (MMP) activity, a neovasculature, and fibrillar collagen scaffolding. We found that enhanced ICAM-l and MCP-1, as well as MMP activity on day 3 and 7 postMI, are present to facilitate the homing, chemotaxis, and migration of circulating cells into the infarct site. The vascular network formed at the infarct site contains a ratio of conduit to exchange vessels that is greater than that for control tissue and therefore its ability to nourish BMDPC for their growth appears to be tenuous. These findings, together with the dense formation of a fibrillar collagen scar beyond week 2, suggest the optimal time to rebuild myocardium from BMDPC resides within 2 week postMI.

AB - The potential for bone marrow-derived progenitor cells (BMDPC) to regenerate myocardial tissue following infarction depends on homing, migration, nourishment, and spatially appropriate growth of BMDPC. Requisite to these objectives is the expression of adhesion molecules (ICAM-1) and chemoattractant cytokines (MCP-1), matrix metalloproteinase (MMP) activity, a neovasculature, and fibrillar collagen scaffolding. We found that enhanced ICAM-l and MCP-1, as well as MMP activity on day 3 and 7 postMI, are present to facilitate the homing, chemotaxis, and migration of circulating cells into the infarct site. The vascular network formed at the infarct site contains a ratio of conduit to exchange vessels that is greater than that for control tissue and therefore its ability to nourish BMDPC for their growth appears to be tenuous. These findings, together with the dense formation of a fibrillar collagen scar beyond week 2, suggest the optimal time to rebuild myocardium from BMDPC resides within 2 week postMI.

UR - http://www.scopus.com/inward/record.url?scp=3042719731&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3042719731&partnerID=8YFLogxK

U2 - 10.1016/j.bbrc.2004.06.034

DO - 10.1016/j.bbrc.2004.06.034

M3 - Article

VL - 320

SP - 907

EP - 913

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

SN - 0006-291X

IS - 3

ER -