Molecular aspects of myocarditis

Neil E. Bowles, Jeffrey Towbin

Research output: Contribution to journalReview article

44 Citations (Scopus)

Abstract

The mechanisms of pathogenesis of myocarditis have remained elusive. Despite the demonstration a decade ago that persistent viral infection of the myocardium occurred in many patients, a clear description of the pathologic progression has not been forthcoming. Over the past year, a number of studies have added to the data defining the crucial roles of cytokine expression in the myocardium and the aberrant induction of apoptosis. Further, a mouse model of myocarditis resulting from the myocardial expression of tumor necrosis factor-α has been described. In addition, the identification of the common coxsackievirus B and adenovirus receptor has offered an explanation for the puzzling observation that these highly distinct virus types both cause cardiac disease. Finally, the near-eradication of endocardial fibroelastosis associated with persistent mumps virus infection by vaccination supports the notion that coxsackievirus B and adenovirus vaccines may help reduce the incidence of myocarditis.

Original languageEnglish (US)
Pages (from-to)179-184
Number of pages6
JournalCurrent Opinion in Cardiology
Volume13
Issue number3
StatePublished - Jun 15 1998
Externally publishedYes

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Myocarditis
Virus Diseases
Myocardium
Adenovirus Vaccines
Endocardial Fibroelastosis
Mumps virus
Human Enterovirus B
Heart Diseases
Vaccination
Tumor Necrosis Factor-alpha
Apoptosis
Cytokines
Viruses
Incidence

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Molecular aspects of myocarditis. / Bowles, Neil E.; Towbin, Jeffrey.

In: Current Opinion in Cardiology, Vol. 13, No. 3, 15.06.1998, p. 179-184.

Research output: Contribution to journalReview article

Bowles, NE & Towbin, J 1998, 'Molecular aspects of myocarditis', Current Opinion in Cardiology, vol. 13, no. 3, pp. 179-184.
Bowles, Neil E. ; Towbin, Jeffrey. / Molecular aspects of myocarditis. In: Current Opinion in Cardiology. 1998 ; Vol. 13, No. 3. pp. 179-184.
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