Molecular cytogenetic analysis of a medulloblastoma with isochromosome 17 and double minutes

Jeffrey R. Sawyer, Charles M. Swanson, Gary J. Roloson, Darryl C. Longee, Frederick Boop, William M. Chadduck

Research output: Contribution to journalArticle

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Abstract

Cytogenetic analysis of a medulloblastoma revealed two abnormal cell lines of 48,XY,+8,+8,-14,+der(14)t(1;14)(q11;p11),i(17q) and 51,XY,+5,+6,+8,+8,-14+20,+der (14)t(1;14)(q11;p11),i(17q),+dmin. The finding of double minute chromosomes in some medulloblastomas has been associated with amplification of the c-myc or N-myc oncogenes. We were unable to detect gene amplification with these probes by Southern blot analysis.

Original languageEnglish (US)
Pages (from-to)181-186
Number of pages6
JournalCancer Genetics and Cytogenetics
Volume57
Issue number2
DOIs
StatePublished - Jan 1 1991

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Isochromosomes
Medulloblastoma
Cytogenetic Analysis
myc Genes
Gene Amplification
Southern Blotting
Chromosomes
Cell Line

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Molecular cytogenetic analysis of a medulloblastoma with isochromosome 17 and double minutes. / Sawyer, Jeffrey R.; Swanson, Charles M.; Roloson, Gary J.; Longee, Darryl C.; Boop, Frederick; Chadduck, William M.

In: Cancer Genetics and Cytogenetics, Vol. 57, No. 2, 01.01.1991, p. 181-186.

Research output: Contribution to journalArticle

Sawyer, Jeffrey R. ; Swanson, Charles M. ; Roloson, Gary J. ; Longee, Darryl C. ; Boop, Frederick ; Chadduck, William M. / Molecular cytogenetic analysis of a medulloblastoma with isochromosome 17 and double minutes. In: Cancer Genetics and Cytogenetics. 1991 ; Vol. 57, No. 2. pp. 181-186.
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