Molecular diagnosis of myocardial disease

Jeffrey Towbin, Neil E. Bowles

Research output: Contribution to journalReview article

18 Citations (Scopus)

Abstract

Myocardial disorders are major causes of morbidity and mortality, including heart failure, sudden death and the need for heart transplantation. The two most common forms of myocardial disorders, dilated cardiomyopathy and hypertrophic cardiomyopathy are paradigms of left ventricular systolic dysfunction and diastolic dysfunction. The genetics of these disorders are increasingly understood with the sarcomere playing a central role in the development of HCM and the link between sarcomere and sarcolemma being key to the development of DCM. In this review, the genetics of the myocardial diseases will be described.

Original languageEnglish (US)
Pages (from-to)587-602
Number of pages16
JournalExpert Review of Molecular Diagnostics
Volume2
Issue number6
DOIs
StatePublished - Nov 1 2002
Externally publishedYes

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Sarcomeres
Inborn Genetic Diseases
Cardiomyopathies
Sarcolemma
Hypertrophic Cardiomyopathy
Dilated Cardiomyopathy
Left Ventricular Dysfunction
Heart Transplantation
Sudden Death
Heart Failure
Morbidity
Mortality

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Molecular Medicine
  • Molecular Biology
  • Genetics

Cite this

Molecular diagnosis of myocardial disease. / Towbin, Jeffrey; Bowles, Neil E.

In: Expert Review of Molecular Diagnostics, Vol. 2, No. 6, 01.11.2002, p. 587-602.

Research output: Contribution to journalReview article

Towbin, Jeffrey ; Bowles, Neil E. / Molecular diagnosis of myocardial disease. In: Expert Review of Molecular Diagnostics. 2002 ; Vol. 2, No. 6. pp. 587-602.
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