Molecular features of heterochromatin condensation

B. A. Hamkalo, K. Lundgren, M. H. Parseghian, Marko Radic, M. Saghbini

Research output: Contribution to journalConference article

Abstract

The goal of this paper is to identify components of interactions in understanding the molecular basis for differential chromatin condensation. Based on the experimental results, ligand-DNA interactions inhibited or reduced the binding of one or more chromosomal proteins involved in condensation. One conserved nonhistone chromosomal protein that exhibits the properties predicted to be required for competition binding is a member of the high mobility group of proteins named HMG-I. A second conserved chromosomal protein known to be involved in chromatin condensation is histone H1. Since this protein exists in 4-5 distinct isoforms in each cell, it is possible that each isoform possesses a distinct and differential ability to condense heterochromatin.

Original languageEnglish (US)
Pages (from-to)72-73
Number of pages2
JournalProceedings - Annual Meeting, Microscopy Society of America
StatePublished - Dec 1 1993
Externally publishedYes
EventProceedings of the 51st Annual Meeting Microscopy Society of America - Cincinnati, OH, USA
Duration: Aug 1 1993Aug 6 1993

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Condensation
Proteins
DNA
Ligands

All Science Journal Classification (ASJC) codes

  • Engineering(all)

Cite this

Hamkalo, B. A., Lundgren, K., Parseghian, M. H., Radic, M., & Saghbini, M. (1993). Molecular features of heterochromatin condensation. Proceedings - Annual Meeting, Microscopy Society of America, 72-73.

Molecular features of heterochromatin condensation. / Hamkalo, B. A.; Lundgren, K.; Parseghian, M. H.; Radic, Marko; Saghbini, M.

In: Proceedings - Annual Meeting, Microscopy Society of America, 01.12.1993, p. 72-73.

Research output: Contribution to journalConference article

Hamkalo, B. A. ; Lundgren, K. ; Parseghian, M. H. ; Radic, Marko ; Saghbini, M. / Molecular features of heterochromatin condensation. In: Proceedings - Annual Meeting, Microscopy Society of America. 1993 ; pp. 72-73.
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